Actively Recruiting
Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles.
Led by University of Seville · Updated on 2026-01-23
8
Participants Needed
1
Research Sites
73 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to investigate how moderate wine consumption influences circulating extracellular vesicles (EVs) in healthy adults. EVs are small particles released by cells that carry proteins, lipids, and genetic material, and play important roles in communication between cells. Participants will consume a single serving of red or white wine, and blood samples will be collected before and after consumption to study changes in the composition and function of EVs. The study will also assess how these EVs affect vascular, immune, and brain-related cells. The results are expected to improve our understanding of how moderate wine intake contributes to cardiovascular and brain health.
CONDITIONS
Official Title
Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy adults aged 35 to 65 years
- Body Mass Index (BMI) between 18.5 and 29.9 kg/m²
- Non-smokers or ex-smokers for at least 12 months
- Moderate alcohol consumers (up to 2 units/day for men, up to 1 unit/day for women)
- Normal fasting glucose and lipid profile at screening
- Willing and able to avoid alcohol, polyphenol-rich foods, and intense exercise for 48 hours before each visit
- Able to understand study procedures and provide written informed consent
You will not qualify if you...
- History or signs of cardiovascular, liver, kidney, thyroid, gastrointestinal, or metabolic diseases, including diabetes, dyslipidemia, or hypertension
- Use of medications or supplements affecting glucose, lipid, or inflammatory metabolism
- Pregnancy or breastfeeding
- Recent or planned blood donation within the study period
- Major weight change (>5% body weight) in the last 3 months
- Participation in another clinical or biomedical study in the past 3 months
- Known allergy or intolerance to wine, alcohol, or components like sulfites
- History of alcohol abuse or inability to abstain from alcohol outside the study
- Unwillingness to receive information about incidental health findings
- Any condition limiting compliance or increasing study risk, such as psychiatric disorders or inability to follow fasting requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Av. de Sánchez Pizjuán, s/n, 41009 Sevilla Facultad de Medicina . Universidad de Sevilla
Seville, Sevilla, Spain, 41009
Actively Recruiting
Research Team
S
Sergio Montserrat-de la Paz, Full Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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