Study of Moderate Red or White Wine Intake on Blood Particles and Healthy Aging in Adults Aged 35 to 65

What this Trial Is About

Researchers are investigating how moderate wine consumption affects circulating extracellular vesicles EVs in healthy adults aged 35 to 65 years. EVs are tiny particles released by cells that carry proteins, fats, and genetic material, playing key roles in cell communication. This study aims to understand how a single serving of red or white wine changes the composition and function of EVs, and how these changes may influence cardiovascular and brain health, including impacts on vascular, immune, and brain-related cells. Participants will be randomly assigned to consume one of three beverages red wine Cabernet Sauvignon, white wine Chardonnay, or water as a control, each dosed at 4 mL per kg of body weight consumed within 15 minutes. Blood samples will be collected at fasting before consumption, at the peak postprandial time 1-2 hours after intake, and at 6 hours post-consumption. The study examines changes in the lipid, protein, and polyphenol content of EVs and their effects on cells related to atherosclerosis and brain aging. During the study, participants will undergo blood draws at three time points to measure EV concentration, size, and detailed cargo changes, as well as plasma glucose, insulin, cholesterol, and inflammatory markers. Researchers will also assess the influence of postprandial EVs on blood-brain barrier models and microglial cells in the lab. The trial includes monitoring various biochemical and cellular outcomes up to 6 hours after beverage intake, providing insights into how moderate wine intake may contribute to healthy aging and disease prevention.

Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles.