Actively Recruiting
Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles
Led by University of Seville · Updated on 2026-01-23
8
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how moderate wine consumption affects circulating extracellular vesicles (EVs) in healthy adults aged 35 to 65 years. EVs are tiny particles released by cells that carry proteins, fats, and genetic material, playing key roles in cell communication. This study aims to understand how a single serving of red or white wine changes the composition and function of EVs, and how these changes may influence cardiovascular and brain health, including impacts on vascular, immune, and brain-related cells. Participants will be randomly assigned to consume one of three beverages: red wine (Cabernet Sauvignon), white wine (Chardonnay), or water as a control, each dosed at 4 mL per kg of body weight consumed within 15 minutes. Blood samples will be collected at fasting (before consumption), at the peak postprandial time (1-2 hours after intake), and at 6 hours post-consumption. The study examines changes in the lipid, protein, and polyphenol content of EVs and their effects on cells related to atherosclerosis and brain aging. During the study, participants will undergo blood draws at three time points to measure EV concentration, size, and detailed cargo changes, as well as plasma glucose, insulin, cholesterol, and inflammatory markers. Researchers will also assess the influence of postprandial EVs on blood-brain barrier models and microglial cells in the lab. The trial includes monitoring various biochemical and cellular outcomes up to 6 hours after beverage intake, providing insights into how moderate wine intake may contribute to healthy aging and disease prevention.
CONDITIONS
Brief Title
Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy adult men and women aged 35 to 65 years
- Body Mass Index (BMI) between 18.5 and 29.9 kg/m�b2
- Non-smokers or ex-smokers for at least 12 months
- Moderate alcohol consumers, defined as �2 units/day for men and �1 unit/day for women
- Normal fasting glucose and lipid profile at screening
- Willing and able to refrain from alcohol, polyphenol-rich foods, and intense exercise for 48 hours before each study visit
- Able to understand the study procedures and provide written informed consent
You will not qualify if you...
- History or clinical evidence of cardiovascular, hepatic, renal, thyroid, gastrointestinal, or metabolic diseases (including diabetes, dyslipidemia, or hypertension)
- Use of medications or supplements known to affect glucose, lipid, or inflammatory metabolism (e.g., statins, corticosteroids, anti-inflammatory drugs)
- Pregnancy or breastfeeding
- Recent blood donation (within the last 3 months) or planned blood donation during the study period
- Major weight change (>5% of body weight) within the last 3 months
- Participation in another clinical or biomedical study within the previous 3 months
- Known allergy or intolerance to wine, alcohol, or its components (e.g., sulfites)
- History of alcohol abuse or inability to abstain from alcohol outside the study context
- Reluctance to receive information about incidental health findings arising from the study
- Any condition judged by the investigators to limit compliance or increase study risk (e.g., psychiatric disorders, inability to adhere to fasting requirements)
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Participants undergo assessments to confirm health status, alcohol consumption habits, and metabolic profiles.
Duration - Each intervention involves a single dosing session with assessments over 6 hours post-consumption; multiple sessions occur due to crossover design.
Participants consume assigned beverages (red wine, white wine, or water) in a crossover design to study the effects on extracellular vesicles and related biomarkers.
1 visit per beverage consumption session with blood samples collected at fasting (0 hours), postprandial peak (1-2 hours), and post-peak (6 hours)
Trial Site Locations
Total: 1 location
1
Av. de Sánchez Pizjuán, s/n, 41009 Sevilla Facultad de Medicina . Universidad de Sevilla
Seville, Sevilla, Spain, 41009
Actively Recruiting
Research Team
S
Sergio Montserrat-de la Paz, Full Professor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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