Actively Recruiting

Phase Not Applicable
Age: 18Years - 50Years
All Genders
Healthy Volunteers
NCT06745479

Decision-Making in Schizophrenia: A Combined Neuroimaging and Experience Sampling Study

Led by Rutgers, The State University of New Jersey · Updated on 2026-03-11

74

Participants Needed

1

Research Sites

129 weeks

Total Duration

On this page

Sponsors

R

Rutgers, The State University of New Jersey

Lead Sponsor

N

National Institute of Mental Health (NIMH)

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this clinical trial is to learn if attention and ways of thinking impact decision-making and brain processes related to decision-making in people with schizophrenia or schizoaffective disorder relative to people without either condition. It will also learn how brain functioning during decision-making relates to real-world decisions made during daily life. The main questions it aims to answer are: * Does paying attention to specific information impact decision-making and brain processes? * Does thinking in a certain way according to specific 'thinking strategies' improve brain processes related to decision-making? * Does brain functioning during decision-making relate to real-world choices to engage in activities? Researchers will compare brain functioning and decision-making on computer tasks of gambling after participants have been trained to use a positive thinking strategy. They will compare what is different in the brain and behavior when participants use this strategy and when they do not. Participants will also answer brief surveys about activities and feelings for a week in their daily lives. Participants will: * Complete several hours of clinical interviewing, cognitive tests, and surveys of about symptoms, experiences, and personality * Complete computer tasks about gambling decisions during MRI brain scanning and while having their visual attention measured using eye-tracking * Complete brief surveys about their activities and feelings 5 times a day for 1 week using a cell phone. Each survey only take several minutes.

CONDITIONS

Official Title

Decision-Making in Schizophrenia: A Combined Neuroimaging and Experience Sampling Study

Who Can Participate

Age: 18Years - 50Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 18 and 50 years
  • Capacity to provide informed consent
  • Fluent in English
  • Willing and able to follow study requirements and complete procedures
  • Cognitive ability with estimated IQ over 70
  • For schizophrenia group: diagnosed with schizophrenia or schizoaffective disorder
  • For control group: matched to schizophrenia group by age, sex, race/ethnicity, and education level
Not Eligible

You will not qualify if you...

  • Intoxication from alcohol or illicit drugs at study visits
  • Current regular use of substances other than nicotine, alcohol, or cannabis
  • Long history of severe substance use disorder except nicotine/tobacco
  • Significant physical health or neurological disorders
  • History of traumatic brain injury with loss of consciousness or neurobehavioral effects
  • Electroconvulsive therapy within one month before participation
  • History of seizures or epilepsy
  • Untreated or unstable psychiatric or medical conditions
  • Intellectual disability
  • Contraindications for MRI scanning
  • For control group: history of substance use disorder or significant psychiatric disorder in self or first-degree relative

AI-Screening

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Trial Site Locations

Total: 1 location

1

Center for Advanced Human Brain Imaging Research

Piscataway, New Jersey, United States, 08854

Actively Recruiting

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Research Team

P

Pariya Chanthasensack, BS

CONTACT

J

John Purcell, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

BASIC_SCIENCE

Number of Arms

1

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