Actively Recruiting
Decoding Epigenetic Mechanisms Driving Immune Evasion in Liver Cancer With Omics Approaches
Led by Niguarda Hospital · Updated on 2026-02-27
270
Participants Needed
1
Research Sites
265 weeks
Total Duration
On this page
Sponsors
N
Niguarda Hospital
Lead Sponsor
S
San Raffaele University Hospital, Italy
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a national, observational, retrospective, cross-sectional, non-profit study focused on patients with HCC. The study aims to characterize the expression and function of novel noncoding regulatory transcripts, including those containing TEsin the microenvironment of liver tumors, with emphasis on their role in T cell dysfunction.
CONDITIONS
Official Title
Decoding Epigenetic Mechanisms Driving Immune Evasion in Liver Cancer With Omics Approaches
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histological or radiological diagnosis of hepatocellular carcinoma (HCC)
- Availability of fresh solid tumor tissue from biopsy or surgical resection and/or archival formalin-fixed paraffin-embedded (FFPE) HCC samples
- Ability to understand and sign an informed consent form
- Known hepatitis B and C status, including antigen status, viral load, genotype, treatment history, and response to therapy
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
ASST GOM Niguarda
Milan, Lombardy, Italy, 20162
Actively Recruiting
Research Team
G
Gianluca Mauri, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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