Actively Recruiting
Decoding Extracellular Vesicles in Hairy Cell Leukemia to Improve Patient Care Management
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2025-01-14
50
Participants Needed
3
Research Sites
89 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the role of extracellular vesicles, tiny particles in the blood that carry proteins, fats, and genetic material, in the environment surrounding Hairy Cell Leukemia (HCL) cells. They believe these vesicles help the leukemia cells survive by affecting nearby immune and supportive cells, possibly helping the cancer evade the immune system and cause bone marrow scarring. The study aims to identify specific vesicle-related signatures that relate to disease outcomes. This national multi-center study does not involve treatment but focuses on analyzing these extracellular vesicles in patients with HCL and healthy volunteers. There are no interventions or drug treatments given. Participants include adults diagnosed with HCL and healthy donors who meet the age and health criteria. Participants will provide blood samples for extracellular vesicle analysis, which will be characterized over one year. The study involves assessments related to the vesicles' properties and their role in the leukemia environment. Researchers will monitor these vesicles to better understand their impact on the disease and patient care management.
CONDITIONS
Official Title
Decoding the Extracellular Vesicles-driven Communication in the Microenvironment of Hairy Cell Leukemia to Improve Patient Care Management
Who Can Participate
Eligibility Criteria
You may qualify if you...
- WHO2022-defined diagnosis of Hairy Cell Leukemia.
- Age �318 years.
- Signed informed consent.
- Healthy volunteers 18 years or older in good health without serious illness.
- Signed informed consent for healthy volunteers.
You will not qualify if you...
- None
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello
Palermo, PA, Italy, 90121
Actively Recruiting
2
Policlinico Santa Maria alla Scotte
Siena, SI, Italy, 53100
Actively Recruiting
3
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy, 40138
Actively Recruiting
Research Team
L
Lucia Catani, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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