Studying and Modifying Brain Activity Related to Negative Emotions with Personalized Brain Stimulation Using Transcranial Magnetic Stimulation TMS

What this Trial Is About

Researchers are studying brain patterns related to negative emotions and testing personalized brain stimulation methods using transcranial magnetic stimulation TMS to disrupt these patterns. The study aims to create a negative affect brain map for each participant using functional MRI and then find the best and worst TMS frequencies to influence negative emotional brain states. This research involves neuromodulation sessions to see if these TMS frequencies can reduce negative emotions in people with rumination, major depressive disorder, or anxiety. The study includes 11 visits over about 10 weeks. It begins with screening, including remote questionnaires and in-person clinical interviews and TMS demonstrations. Participants then undergo MRI scans combined with TMS to identify optimal stimulation frequencies. Two separate 3-day sessions of repetitive TMS using the optimal and the least optimal frequencies are provided to compare their effects. Each neuromodulation session lasts about 1.5 hours, with assessments before, during, and after. Participants will complete MRI scans, computerized tasks, and questionnaires throughout the study. The research team will monitor changes in rumination scores to evaluate TMS impact. Safety and tolerance of TMS will be assessed during sessions. Participants may receive compensation for their time and involvement. The total study duration depends on scheduling but is approximately 10 weeks from screening to final assessments.

Decoding and Modulating Affective Brain States