Actively Recruiting
Decolonization to Reduce After-Surgery Events of Surgical Site Infection
Led by University of California, Irvine · Updated on 2025-07-28
2700
Participants Needed
4
Research Sites
306 weeks
Total Duration
On this page
Sponsors
U
University of California, Irvine
Lead Sponsor
U
University of California, Davis
Collaborating Sponsor
AI-Summary
What this Trial Is About
The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700 participants randomized 1:1) clinical trial to reduce post-discharge surgical site infection following open colon or small bowel surgery by comparing chlorhexidine bathing plus nasal mupirocin in the 30 days following discharge to soap without antiseptic properties (placebo) and placebo nasal ointment. This trial seeks to enhance the care of the 675,000 patients annually who undergo colon and small bowel surgery by finding simple and efficacious interventions to reduce SSI.
CONDITIONS
Official Title
Decolonization to Reduce After-Surgery Events of Surgical Site Infection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Recent open (not solely laparoscopic) surgery involving an abdominal incision within the past 14 days
- For cesarean section, body mass index (BMI) of 40 or higher
- Able to communicate regularly by phone
- Able to bathe, shower, or have this task performed by a caregiver
You will not qualify if you...
- Transfer to an acute care hospital
- Discharged to receive end-of-life hospice measures
- Discharged more than 14 days after surgery
- Allergic to mupirocin and/or chlorhexidine
- Active infection at enrollment requiring systemic antibacterial agents
- Surgical incision not closed at discharge
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Hoag Memorial Hospital Presbyterian
Newport Beach, California, United States, 92663
Actively Recruiting
2
University of California, Irvine Medical Center
Orange, California, United States, 92868
Actively Recruiting
3
University of California, Davis Medical Center
Sacramento, California, United States, 95817
Actively Recruiting
4
University of California, San Francisco Medical Center
San Francisco, California, United States, 94143
Actively Recruiting
Research Team
S
Susan Huang, MD, MPH
CONTACT
R
Raveena Singh, MA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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