Deep Brain Stimulation of the Cerebellum for Treating Post-Stroke Spasticity and Improving Motor Function

What this Trial Is About

Researchers are investigating whether deep brain stimulation DBS can improve rehabilitation and functional recovery in patients with post-stroke spasticity. The study aims to find out if DBS is effective and which stimulation frequency works best. Participants are adults who have experienced a stroke and have persistent spasticity despite prior rehabilitation. Participants will undergo surgery to implant a DBS electrode targeting the dentate-rubro-thalamic tract near the dentate nucleus of the cerebellum on the side affected by spasticity. They will receive stimulation at three different frequencies 130 Hz, 70 Hz, and 30 Hz, each followed by a 4- to 6-week rehabilitation program. After each rehabilitation period, participants return for clinical evaluations to assess the effects of the stimulation frequency. Throughout the study, patients will be evaluated using clinical scales such as the Fugl-Meyer Assessment FMA, Ashworth Scale, Motor Assessment Scale MAS, and Modified Rankin Scale to measure improvements in motor function and spasticity. The study includes follow-up visits after each stimulation period, with a total participation duration covering the three rehabilitation cycles. Researchers will compare outcomes at different frequencies to understand the clinical impact of DBS on post-stroke spasticity.

Deep Anterior Cerebellar Stimulation in Treatment of Poststroke Spasticity and Motor Function Impairment.