Actively Recruiting
Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor
Led by Massachusetts Eye and Ear Infirmary · Updated on 2025-12-02
120
Participants Needed
1
Research Sites
271 weeks
Total Duration
On this page
Sponsors
M
Massachusetts Eye and Ear Infirmary
Lead Sponsor
M
Massachusetts General Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goals of this project are 1) to determine the incidence of neurological voice disorders in patients with dystonia and essential tremor undergoing deep brain stimulation (DBS), 2) investigate the neuroimaging and intracranial neurophysiology correlates of voice dysfunction in these subjects, and subsequently 3) determine the effects of DBS on voice function.
CONDITIONS
Official Title
Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical indications for DBS implantation as determined by a multidisciplinary movement disorders board, including a definitive diagnosis of essential tremor or dystonia
- Medically refractory disease
- Adequate performance on neuropsychological evaluation by a licensed clinical neuropsychologist
- Ability to comply with test directions, complete pre-operative task training, and provide informed consent
- Age between 18 and 80 years
You will not qualify if you...
- Inability to understand or perform the study task during pre-surgery training
- Significant hearing loss
- Cortical venous anatomy that may block ECoG electrode placement as seen on MRI or during surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital, University of California San Francisco, University of Utah
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
K
Kristina Simonyan, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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