Actively Recruiting
Deep Brain Stimulation for Severe Self-Injurious Behaviour in Children
Led by The Hospital for Sick Children · Updated on 2026-03-27
25
Participants Needed
1
Research Sites
120 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Deep Brain Stimulation for the Treatment of Severe Refractory Self-Injurious Behaviour in Children with Autism Spectrum Disorder: A Randomized Trial To evaluate the effectiveness of deep brain stimulation (DBS) of the nucleus accumbens for the treatment of severe refractory, repetitive self-injurious behavior (SIB) in children with Autism Spectrum Disorder. Secondary objectives are to examine the effects of DBS on subtypes of SIB through functional analysis.
CONDITIONS
Official Title
Deep Brain Stimulation for Severe Self-Injurious Behaviour in Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 5-17 at the time of enrollment
- DSM-5 diagnosis of Autism Spectrum Disorder
- History of repetitive self-injurious behaviour, ongoing or intermittent, causing physical injury
- Foreseeable risk of serious future self-harm
- Screening indicating presence of subtype 2 or 3 automatically reinforced self-injurious behaviour
- Failure or non-eligibility of medical therapy with ongoing self-injurious behaviours for 6 months or more
- Parents or legal guardians able to provide informed written consent
- Ability to comply with all testing, follow-up visits, and study protocols for 12 months after the study
You will not qualify if you...
- Substance dependence or abuse in the last 6 months, excluding caffeine and nicotine
- Any contraindication to MRI scanning
- Presence of cardiac arrhythmias or other cardiac, respiratory, renal, or endocrine conditions posing significant surgical risk
- Pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G1X8
Actively Recruiting
Research Team
G
George M Ibrahim, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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