Actively Recruiting
Deep Brain Stimulation for Visuomotor Function in Parkinson's Disease
Led by VA Office of Research and Development · Updated on 2026-01-07
40
Participants Needed
1
Research Sites
195 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Inability to align and refocus the eyes on the objects at different depths, i.e., vergence impairment, frequently affects the quality of life in patients with Parkinson's disease. Our study aims to understand the location-specific effects of subthalamic region deep brain stimulation on vergence by integrating the patient-specific deep brain stimulation models and high-resolution eye-tracking measures. The knowledge gained will allow us to find the most beneficial stimulation location and parameters for improving binocular coordination and vergence while preserving the ability to treat motor symptoms in Parkinson's disease.
CONDITIONS
Official Title
Deep Brain Stimulation for Visuomotor Function in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Parkinson's disease with bilateral STN DBS
- Availability of pre-operative MR images (with a T1-weighted, gradient-echo sequence) and ability to get post-operative MRI or CT scans
- Hoehn and Yahr stage 2-4 when off medication, and a stable antiparkinsonian medication regimen and DBS parameter settings
You will not qualify if you...
- Previous surgical therapy for Parkinson's disease (other than DBS)
- Dementia
- Clinically significant untreated depression or anxiety
- Clinical features suggestive of atypical parkinsonism
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Louis Stokes VA Medical Center, Cleveland, OH
Cleveland, Ohio, United States, 44106-1702
Actively Recruiting
Research Team
A
Aasef G Shaikh, MD PhD
CONTACT
M
Monica O'Loughlin
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here