Actively Recruiting
Deep Functional Phenotyping of the ALA Lung Health Cohort
Led by Johns Hopkins University · Updated on 2026-03-06
1000
Participants Needed
12
Research Sites
128 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to learn about lung structure and function in a group of 1000 healthy people aged 25 to 35. The main questions it aims to answer are whether people's bodies, environment, and general lung health are associated with: * the structure of the participants lungs' airways, * the structure of blood vessels in the participants lungs and heart, and * the participants lungs' ability to exchange gases. Participants will take four different lung function tests to measure lung function, including: * air movement in the lungs (oscillometry) * lung size (slow vital capacity (SVC) and functional residual capacity (FRC) * gas transfer in the lungs (diffusing capacity for carbon monoxide (DLCO).
CONDITIONS
Official Title
Deep Functional Phenotyping of the ALA Lung Health Cohort
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 25 to 35 years at the time of the baseline examination
- Able to read and understand English or Spanish
- Has a social security number
- Resident of the United States for at least 12 months before the examination
- Willing to provide contact information for at least two proxies who can provide whereabouts and vital status information
You will not qualify if you...
- Severe asthma, defined as current Global Initiative for Asthma Step 4 or higher therapy or multiple unscheduled healthcare visits or hospitalization for asthma in the past 12 months
- History of any chronic lung disease other than asthma, including COPD, cystic fibrosis, pulmonary fibrosis, or pulmonary hypertension
- Current pregnancy
- History of cancer other than non-melanoma skin cancer
- Diagnosed cardiovascular diseases such as congenital heart disease or coronary heart disease
- Inability to comply with study procedures or provide informed consent
- Inability to perform study measurements
- Inability to be contacted by phone or email
- Any condition the physician believes puts the participant at risk by participating
- Institutionalization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 12 locations
1
University of Alabama
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
University of California, Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
3
National Jewish Health
Denver, Colorado, United States, 80206
Actively Recruiting
4
Nemours Children's Jacksonville
Jacksonville, Florida, United States, 32207
Actively Recruiting
5
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
6
University of Kansas
Kansas City, Kansas, United States, 66103
Actively Recruiting
7
Johns Hopkins University
Baltimore, Maryland, United States, 21218
Actively Recruiting
8
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
9
Duke University
Durham, North Carolina, United States, 27710
Actively Recruiting
10
Wake Forest School of Medicine
Winston-Salem, North Carolina, United States, 27104
Actively Recruiting
11
University of Pittsburgh - Emphysema/COPD Research Center
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
12
University of Vermont
Burlington, Vermont, United States, 05446
Actively Recruiting
Research Team
M
Meredith McCormack, MD
CONTACT
A
Alexis Rea, MPH
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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