Impact of Deep Neuromuscular Blockade on Postoperative Pain in Children Aged 2 Months to 7 Years Undergoing Laparoscopic Surgery

What this Trial Is About

This research aims to evaluate how different levels of neuromuscular blockade affect postoperative pain in children aged over 2 months to under 7 years undergoing laparoscopic surgery with general anesthesia. The study focuses on understanding pain control in this young patient group during recovery after surgery. The trial is a prospective randomized controlled study led by Seoul National University Hospital. Participants will receive either a moderate or deep neuromuscular blockade during surgery. Moderate blockade is maintained by a continuous infusion of rocuronium at 0.2 mgkghr to keep the Train-of-four count between 1 and 3, while deep blockade uses a higher infusion rate of 0.6 mgkghr to achieve a Train-of-four count of 0. These two groups will be compared to assess differences in pain and recovery. Throughout the study, children will be closely monitored after surgery with assessments including the Analgesia Nociception Index 30 minutes after arrival in the recovery room, pain scales, emergence delirium scores, time to extubation, recovery room stay length, and medication use. Additional monitoring includes surgical and respiratory parameters during surgery, as well as any complications up to one month after discharge. The study will collect detailed data on pain and recovery outcomes over a 24-hour period following surgery.

Deep Neuromuscular Blockade on Postoperative Pain