Detailed Study of Blood Cells and Circulating Substances in Adults with Metabolic Diseases Including Diabetes, Obesity, and Fatty Liver Disease

What this Trial Is About

Researchers are conducting an observational study to explore the differences in blood cells and circulating molecules in adults with metabolic diseases such as diabetes, obesity, and non-alcoholic fatty liver disease compared to healthy adults. The study aims to measure both the quantity and characteristics of platelets, leukocytes, and other circulating factors to better understand these conditions shared underlying mechanisms. Participants will be assessed across several groups based on liver fibrosis risk, steatosis presence, and glucose metabolism status. Diagnostic tests include a 75g oral glucose tolerance test with multiple timed blood draws, liver ultrasound to detect fat accumulation, FibroScan to measure liver stiffness, and MRI to precisely quantify liver fat. These tests help categorize participants and evaluate differences in blood components. During the study, participants undergo blood sample collections and various diagnostic scans on the same day to assess platelet and white blood cell qualities and quantities. Researchers will analyze markers like neutrophil and monocyte function, various interleukins, and other blood factors. The study monitors these outcomes within one day of testing, aiming to deepen understanding of metabolic disease impacts on blood and liver health.

Deep Phenotyping of Peripheral Blood Cells and Circulating Factors in Metabolic Diseases