Actively Recruiting
Deep rTMS for Mild Neurocognitive Disorder in Older Adults
Led by St. Joseph's Healthcare Hamilton · Updated on 2025-10-06
30
Participants Needed
1
Research Sites
70 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to: (1) assess the feasibility and tolerability of three deep transcranial magnetic stimulation (dTMS) coils H1, H4, and H7 in older adults with mild neurocognitive disorder (mild NCD); and (2) evaluate changes in cognition through neuropsychological testing, brain activity through EEG, and mood and sleep through self-report questionnaires. Participants will be assigned to one of three arms: H1- coil vs. H4-coil vs. H7-coil, and all participants will complete assessments examining dTMS side effects, mental health symptoms, and cognition. EEG, questionnaires, and CNS vital signs will be measured at baseline, midpoint (after 10th session- before dTMS treatment on visit 11), and end point, as well as follow up. Collectively, the study will address the absolute and differential feasibility and tolerability of the H1, H4 and H7 coils to provide preliminary data for a future randomized controlled trial comparing this novel intervention to a sham stimulation (placebo) control.
CONDITIONS
Official Title
Deep rTMS for Mild Neurocognitive Disorder in Older Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 60 to 90 years
- Able to provide informed consent
- Subjective mild decline in cognitive function over the past year
- Mild cognitive impairment
- Independence in everyday activities
- Independently mobile (able to get in and out of a chair)
- Stable dosages of psychotropic medications for at least 4 weeks before screening
You will not qualify if you...
- Current treatment or need for treatment for bipolar I or II disorder or psychotic disorder
- Active suicidal behavior
- Severe depression or anxiety
- Neurological or psychiatric disorders causing cognitive deficits
- Impairment in basic or instrumental daily activities
- Substance use disorder (except tobacco) in past 3 months
- Contraindications to rTMS: intracranial or metal implants in the head or nearby areas that cannot be safely removed, history of epilepsy or seizures, unstable medical conditions, pacemaker or implantable cardioverter-defibrillators, current use of bupropion or high-dose benzodiazepines
- Severe literacy, visual, or hearing issues affecting participation
- Frequent migraines or headaches (weekly or more)
- Frequent dizziness or vertigo
- Living outside the Greater Hamilton Area or neighboring regions
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Peter Boris Centre for Addictions Research, St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada, L9C 0E3
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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