Actively Recruiting
DEEP Substrate Mapping Versus Activation Mapping for VT
Led by IRCCS Ospedale San Raffaele · Updated on 2026-03-27
222
Participants Needed
1
Research Sites
154 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Substrate-based DEEP mapping and activation mapping are two of the main techniques used for guiding ventricular tachycardia (VT) ablation. There is no data comparing directly the extent of applicability, procedural results, and the long-term outcomes between the two mapping strategies.This randomized clinical trial aims to test whether activation mapping is superior to DEEP mapping to reduce ventricular tachycardia recurrence. The primary endpoint of the study is to compare recurrence-free survival rate of ventricular tachycardia at 12 months and procedural feasibility of substrate-based DEEP mapping versus activation mapping for VT ablation.
CONDITIONS
Official Title
DEEP Substrate Mapping Versus Activation Mapping for VT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with an implanted ICD (all brands)
- Patients indicated for ventricular tachycardia ablation, including first and redo procedures, supported by EnSite 3D mapping system
- Disease causes include previous myocardial infarction, myocarditis, or arrhythmogenic right/left ventricular dysplasia
- Age 18 years or older
- Willing and able to give informed consent and comply with study assessments
You will not qualify if you...
- Contraindication to anticoagulants
- Presence of thrombi
- Presence of mitral or aortic prosthetic valve
- Recent (less than 3 months) myocardial infarction, unstable angina, or coronary artery bypass
- Ventricular tachycardia due to reversible pathology
- Life expectancy less than 1 year
- Contraindications to ablation or diagnostic catheters or cardiac catheterization
- Female who is pregnant, lactating, or planning pregnancy during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
San Raffaele Hospital
Milan, Lombardy, Italy, 20132
Actively Recruiting
Research Team
A
Andrea Radinovic, MD
CONTACT
A
Anna Montagna, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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