Deep Transcranial Magnetic Stimulation Targeting Brain Networks for Treating Methamphetamine Use Disorder in Adults

What this Trial Is About

Researchers are evaluating the use of deep transcranial magnetic stimulation dTMS as a potential treatment for Veterans with moderate to severe methamphetamine use disorder MUD. This study investigates a novel approach using H4 coils designed to target deeper and broader brain areas, including the bilateral insula, which is part of the brains salience network associated with addiction and relapse risk. The goal is to better understand how this innovative brain stimulation may influence brain function and treatment outcomes for MUD. Participants will be randomly assigned to receive either active dTMS or sham dTMS using the H4 coil. Treatments consist of 30 sessions administered three times daily over 10 consecutive business days, with each session lasting about 30 minutes. The active coil aims to modulate key brain circuits involved in addiction, while the sham coil provides a comparison to evaluate the true effects of the stimulation. During the study, participants will undergo assessments shortly after treatment to evaluate insula function and other salience network activity. Researchers will also track the percentage of days participants remain abstinent and whether relapse occurs over a three-month period following treatment. The study includes careful monitoring to ensure participants safety and adherence, with a total participation timeline extending at least three months after treatment.

Deep TMS of Neural Circuits Associated With Stimulant Use Disorder