Defining the Basis of Fibromuscular Dysplasia: The Define-FMD Study

What this Trial Is About

Researchers are studying Fibromuscular Dysplasia (FMD), Spontaneous Coronary Artery Dissection (SCAD), and Cervical Artery Dissection (CvAD) to better understand the biological mechanisms behind these related artery disorders. The study aims to compare the molecular, genetic, and functional profiles of these diseases by analyzing fibroblasts and other biological samples from patients and healthy individuals. This research expands on earlier work by including a comprehensive systems genetics approach to reveal key gene networks involved in these conditions. Participants include individuals diagnosed with FMD, SCAD, or CvAD as well as healthy controls matched by age and gender. The study collects fibroblasts, DNA, plasma, and serum samples to create a library for detailed molecular and genomic analysis. The research involves a one-time collection and analysis of these samples to identify regulatory gene networks and molecular features associated with the diseases. During the study, participants provide informed consent and undergo sample collection at enrollment. Researchers perform RNA sequencing and measure circulating cytokines to understand gene regulation and disease drivers. The primary measurement is the identification of key regulatory gene networks at the time of enrollment. The study also monitors molecular and genomic features to cross-compare these artery conditions. Participation involves a single visit for data and sample collection with no ongoing treatment or follow-up required.

Defining the Basis of Fibromuscular Dysplasia (FMD)