Actively Recruiting
Defining Outcome Measures for Behavioural and Emotional Problems in Dystrophinopathies
Led by University College, London · Updated on 2024-09-03
100
Participants Needed
1
Research Sites
120 weeks
Total Duration
On this page
Sponsors
U
University College, London
Lead Sponsor
S
Sarepta Therapeutics, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
Study aims to develop and to evaluate the neurophysiological and physiological response to a classical conditioning task.To better understand how Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD) impacts mental health and how to assess it. Participants invited to complete questionnaires about behaviour, cognitive function and social interactions, complete computer tasks and have an optional MRI brain scan,
CONDITIONS
Official Title
Defining Outcome Measures for Behavioural and Emotional Problems in Dystrophinopathies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male participants aged 7 to 17 years
- Genetically confirmed diagnosis of Duchenne Muscular Dystrophy (DMD) or Becker Muscular Dystrophy (BMD)
- For DMD: mutation causing loss of Dp427 alone or both Dp427 and Dp140
- For BMD: mutation reducing expression of Dp427 alone or both Dp427 and Dp140
- Ability to provide consent or assent
- Control participants must be male, aged 7 to 17 years, with ability to consent or assent
You will not qualify if you...
- Significant visual or hearing impairment
- Specific phobias or sensory sensitivities to stimuli similar to those used in the study
- Current participation in a clinical trial involving a new drug targeting dystrophin
- Inability to provide consent or assent, including severe learning disability preventing assent
- For control participants: any neurological or psychiatric diagnosis
- MRI exclusions including claustrophobia, pacemakers, nerve stimulators, intracranial or ocular metallic fragments, cochlear implants, ferromagnetic implants, inability to lie supine for 45 minutes, no general practitioner, or severe learning disability requiring general anesthesia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UCL GOS Institute of Child Health
London, United Kingdom, WC1N 1EH
Actively Recruiting
Research Team
A
Anna Kolesnik, Dr
CONTACT
N
Natasha Aslam, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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