Measuring Behavioural and Emotional Outcomes in Boys Aged 7 to 17 with Duchenne and Becker Muscular Dystrophies

What this Trial Is About

Researchers are studying how Duchenne Muscular Dystrophy DMD and Becker Muscular Dystrophy BMD affect mental health by evaluating neurophysiological and physiological responses to a classical conditioning task. This investigation aims to understand how different genetic types of DMD and BMD relate to emotional and behavioral characteristics. The goal is to develop a comprehensive test battery suitable for future trials targeting brain function improvement. Participants will complete questionnaires on behavior, cognitive function, and social interactions, as well as perform computer-based tasks that measure emotional responses. Some participants may also have an optional MRI brain scan. The study uses a classical conditioning task to record responses such as skin conductance, heart rate, and pupil reactions. The research includes groups of DMD, BMD, and control participants. During the study, participants will undergo various behavioral assessments including the Social Responsiveness Scale, ADHD Rating Scale, Child Behaviour Checklist, and others. The team will measure primary outcomes like differences in response to aversive stimuli among groups over an average of two years. Secondary outcomes include studying learning, habituation, and extinction patterns. Safety and participation are monitored throughout the study period, which involves multiple assessments and optional imaging.

Defining Outcome Measures for Behavioural and Emotional Problems in Dystrophinopathies