Assessing Risk of Dangerous Ventricular Arrhythmias in Genetic Cardiomyopathy Patients with Early-Onset Atrial Fibrillation

What this Trial Is About

Researchers are investigating how electrophysiologic mapping and cardiac MRI can identify patients with genetic forms of cardiomyopathy who are at high risk for dangerous ventricular arrhythmias. This observational study focuses on understanding the prevalence and mechanisms of inducible ventricular tachycardia, as well as mapping the origins and scar tissue related to ventricular arrhythmias in patients with genetic variants linked to cardiomyopathy. The study is motivated by findings that certain genetic variants may indicate an increased risk of life-threatening arrhythmias, especially in early-onset atrial fibrillation cases. Participants are divided into three groups based on genetic testing those with pathogenic variants in the TTN gene, those with variants in other cardiomyopathy-related genes, and those without such variants. All participants undergo cardiac MRI before their scheduled catheter-based ablation procedures for atrial fibrillation, premature ventricular contractions, or ventricular tachycardia. During these procedures, voltage mapping and programmed ventricular stimulation are performed to analyze ventricular tachycardia inducibility and scar tissue in the basal left ventricle. Throughout the study, participants will be evaluated through imaging and electrophysiologic assessments during their ablation procedures. Researchers will collect data on ventricular tachycardia inducibility, the location of ventricular ectopy, and the presence of scar tissue. The study aims to better understand arrhythmia risks in genetic cardiomyopathy and improve precision medicine approaches. The total duration of participation varies with the patients scheduled clinical procedures and follow-up assessments.

Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies