Actively Recruiting
Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies
Led by Vanderbilt University Medical Center · Updated on 2026-05-06
200
Participants Needed
1
Research Sites
311 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to determine if electrophysiologic mapping and cardiac MRI can help identify patients that have genetic forms of cardiomyopathy that are at high risk for development of dangerous ventricular arrhythmias. The investigators aim to study: 1. the prevalence and mechanism of inducible ventricular tachycardia 2. pace-mapping to define the site of origin of ventricular arrhythmias 3. voltage mapping to define low voltage scar substrate in the basal LV to determine the risk of development of ventricular arrhythmias in patients with genetic forms of cardiomyopathy. Participants will undergo cardiac MRI before their scheduled procedure and voltage mapping during their scheduled procedure as part of data collection.
CONDITIONS
Official Title
Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 and older
- Diagnosed with atrial fibrillation, frequent premature ventricular contractions, or ventricular tachycardia before age 60
- Scheduled for catheter-based atrial fibrillation ablation (new or repeat), premature ventricular contraction ablation, or ventricular tachycardia ablation
- Able to provide written, informed consent
- Have a pathogenic or likely pathogenic variant in TTN or another cardiomyopathy gene (cases) or identified as a genotype-negative control
You will not qualify if you...
- Diagnosed with a genetic cardiomyopathy or arrhythmia syndrome before the ablation procedure
- Variant of uncertain significance in the 'possibly pathogenic' subgroup (control group only)
- Previous premature ventricular contraction or ventricular tachycardia ablation
- Left ventricular ejection fraction less than 20%
- Have a prosthetic mitral or aortic valve
- Contraindication to heparin
- Prior myocardial infarction
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
Research Team
D
Dakota Graherr, RN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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