Actively Recruiting
Dehydration, Rehydration, and Impact on Physiology
Led by Texas Tech University · Updated on 2025-09-17
15
Participants Needed
1
Research Sites
72 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Our goal is to determine whether hydration status influences inflammation, and overall physiological performance in adults aged 45-65. Aim 1: The effects of 4-day mild dehydration followed by 4-day rehydration (defined as approximately 2-3% body mass loss) on H2O2, upstream inflammatory signal (NFkB), mitochondrial fragmentation, and autophagy in circulating PBMCs. Aim 2: The effects of 4-day mild dehydration followed by 4-day rehydration (defined as approximately 2-3% body mass loss) on fasting glucose, sleep performance, and strength performance. Participant will: complete a 4-day hydration protocol, followed by a 4-day dehydration protocol, and then a 4-day rehydration protocol. attend five laboratory visits for testing: Day 1: Informed consent and familiarization Day 2: Pre-hydration testing (before the 4-day hydration protocol) Day 3: Pre-dehydration testing (before the dehyration protocol) Day 4: Post-dehydration testing (after the dehydration protocol) Day 5: Post-rehydration testing (after the rehydration protocol)
CONDITIONS
Official Title
Dehydration, Rehydration, and Impact on Physiology
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Apparently healthy adults
- Aged between 45 and 65 years
- Body mass index (BMI) less than 30 kg/m2
- Body weight at least 110 pounds
You will not qualify if you...
- Currently pregnant
- Diagnosed with Type 1 or Type 2 Diabetes
- Have chronic kidney disease or history of kidney stones
- Have high blood pressure (hypertension)
- Taking medications that cause fluid retention such as corticosteroids, NSAIDs, hormonal therapies, antihypertensives, psychiatric medications, or vasodilators
- Taking medications that reduce fluid retention such as diuretics or RAAS inhibitors (e.g., ACE inhibitors and ARBs)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Texas Tech University
Lubbock, Texas, United States, 79409
Actively Recruiting
Research Team
H
Hui Ying Luk, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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