Actively Recruiting
Delayed Against Rapid Sequence Induction in Adults With Medical Diseases Undergoing Emergency Endotracheal Intubation.
Led by Leipzig University Medical Center · Updated on 2025-07-04
200
Participants Needed
1
Research Sites
122 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if it is feaseble to conduct a superiority trial comparing two methods for endotracheal intubation in critically ill patients. It will also learn about validity of outcomes regarding endotracheal intubation. The main questions it aims to answer are: * Does performing intubation via Delayed Sequence Induction lower the incidence of severe hemodynamic complications compared to Rapid Sequence Induction? * How are hemodynamic complications in the severely ill to be measured in order to minimize bias? Participants will: * receive emergency endotracheal intubation via Delayed or Rapid Sequence induction * receive a phone call 90 days after endotracheal intubation * outcome parameters outside of follow up phone calls will be routinely collected during the regular ICU-stay, there won't be any additional testing
CONDITIONS
Official Title
Delayed Against Rapid Sequence Induction in Adults With Medical Diseases Undergoing Emergency Endotracheal Intubation.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients 18 years or older in need of emergency endotracheal intubation in the following 60 minutes.
- The planned operator routinely performs endotracheal intubation in critically ill patients.
You will not qualify if you...
- Endotracheal intubation during cardiopulmonary resuscitation or unstable return of spontaneous circulation with high-dose vasopressors.
- Increased risk for the patient or other reasons that make participation not justifiable, such as active oral bleeding.
- Known allergy to Ketamine, Esketamine, Midazolam, or Rocuronium.
- Known contraindication against Ketamine, Esketamine, Midazolam, or Rocuronium.
- Known or expected difficult airway requiring awake fiberoptic intubation.
- Women who are pregnant or breastfeeding.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Interdisciplinary Medical ICU, Leipzig Medical University Center
Leipzig, Saxony, Germany, 04317
Actively Recruiting
Research Team
A
Anton J Pelka
CONTACT
S
Sirak Petros, Prof. Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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