Actively Recruiting
Dementia Risk Registry for Young and Middle-aged CSVD Patients in the Next 10 Years
Led by Zhejiang Provincial People's Hospital · Updated on 2025-05-21
1000
Participants Needed
1
Research Sites
569 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Age-related cerebral small-vessel disease (CSVD) is a major cause of dementia, predominantly affecting individuals over 60 years of age, with a prevalence exceeding 70% in the elderly population. However, the correlation between the burden of CSVD and the progression of cognitive impairment in young and middle-aged individuals remains uncertain. DREAM-10 is an observational, prospective study that enrolled individuals aged 30-60 years, who were free from known dementia but exhibited imaging markers related to CSVD. Through prospective registration and follow-up, this study will collect data on patients with CSVD, including clinical information, neuropsychological assessments, multimodal Magnetic Resonance Images (MRI) and retinopathy characterized by Optical Coherence Tomography Angiography (OCTA). CSVD related features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, brain atrophy, cortical superficial siderosis. Utilizing this data, the researchers aim to investigate the potential dementia risk among young and middle-aged individuals with CSVD over the forthcoming decade, along with identifying its predictive factors.
CONDITIONS
Official Title
Dementia Risk Registry for Young and Middle-aged CSVD Patients in the Next 10 Years
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with any CSVD-related MRI imaging markers, including recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and superficial cortical siderosis
- Aged from 30 to 60 years
- Signed informed consent
You will not qualify if you...
- Unable to cooperate with inspectors
- Known dementia
- Other cognitive diseases such as Alzheimer's disease, Parkinson's disease, or thyroid disease
- Serious systemic illnesses including heart, liver, kidney disease or major mental illness
- Contraindications for imaging examination
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, China, 310000
Actively Recruiting
Research Team
S
Sheng Zhang, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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