Observational Study on Dementia Risk in Adults Aged 30 to 60 with Cerebral Small Vessel Disease DREAM-10

What this Trial Is About

Researchers are investigating age-related cerebral small-vessel disease CSVD, a common cause of dementia especially in people over 60, to understand its impact on younger adults aged 30 to 60. This observational, prospective study follows individuals without diagnosed dementia but showing brain imaging signs of CSVD, aiming to track cognitive changes and potential dementia risk over a 10-year period. The study is sponsored by Zhejiang Provincial Peoples Hospital and focuses on identifying factors predicting dementia in these younger and middle-aged adults. Participants in this study will be observed without receiving any interventions. Data collection includes clinical information, detailed neuropsychological tests, multimodal magnetic resonance imaging MRI, and retinal imaging using Optical Coherence Tomography Angiography OCTA. Imaging features evaluated include small subcortical infarcts, lacunes, white matter changes, perivascular spaces, microbleeds, brain atrophy, and cortical siderosis. Follow-up assessments are scheduled at baseline, 3 months, 6 months, and then yearly for up to 10 years. During the study, participants will undergo repeated evaluations including the Mini-Mental State Examination MMSE to monitor cognitive function. Additional measures include MRI markers of small vessel disease progression, blood flow density, vascular perfusion area, retinal thickness, nerve fiber layer thickness, brain connectivity changes, white matter integrity, and monitoring of cerebrovascular or cardiovascular events and mortality. This comprehensive monitoring supports understanding the long-term risks and disease progression associated with CSVD in younger adults.

Dementia Risk Registry for Young and Middle-aged CSVD Patients in the Next 10 Years