Actively Recruiting
DeMONSTRATE-TB Study in Ethiopia Testing Enhanced Community TB Prevention and Care to Reduce Tuberculosis Incidence
Led by Management Sciences for Health · Updated on 2024-12-05
131438
Participants Needed
2
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Ending tuberculosis TB in Ethiopia by 2035 requires reducing TB notifications by at least 15% annually through effective prevention and care strategies. This trial evaluates whether a community-wide enhanced TB prevention therapy TPT combined with optimized TB care can accelerate the drop in TB cases. The study also aims to assess community acceptance, provider support, policymaker views, and cost-effectiveness to help develop a TB elimination framework for high-burden areas in Ethiopia. Participants will be in one of two groups one receiving an enhanced community-wide TB intervention, including intensive screening, health education, contact investigations, targeted TB diagnosis, optimized HIV screening and TPT for people living with HIV, and community awareness activities the other group will receive standard TB care per Ethiopias national guidelines. The study lasts up to two years, with ongoing semi-annual TB screenings. Throughout the study, participants will undergo regular TB screenings every six months to measure TB prevalence at the population level. Researchers will also track changes in TB treatment outcomes from the start to two years later. The study involves community-based monitoring and health education efforts, with a total participation period of up to two years to evaluate the impact of the enhanced interventions on TB rates and treatment success.
CONDITIONS
Brief Title
DeMONSTRATE-TB Study in Ethiopia
Research Team
O
Oumer Ali, PhD
Z
Zewdu Dememew, MD, PhD
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
