Actively Recruiting
Dental Cleaning to Prevent Chronic Graft-Versus-Host Disease
Led by Fred Hutchinson Cancer Center · Updated on 2026-04-23
45
Participants Needed
1
Research Sites
153 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial evaluates the feasibility and effectiveness of a post-transplant dental cleaning for the prevention of chronic graft versus host disease (GVHD) in patients undergoing an allogeneic hematopoietic cell transplant (HCT). HCT is the only curative treatment for some types of blood cancer. Unfortunately, this approach can lead to the development of GVHD, which is a disease caused when cells from a donated stem cell graft attack the normal tissue of the transplant patient. Some research has shown that the bacteria that is present in the dental plaque soon after transplant may affect the development of chronic GVHD. Dental cleanings prior to transplant are part of the normal standard of care for patients undergoing HCT. Adding an additional cleaning shortly after HCT may be effective for preventing the development of chronic GVHD.
CONDITIONS
Official Title
Dental Cleaning to Prevent Chronic Graft-Versus-Host Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Undergoing T-replete allogeneic hematopoietic cell transplantation for any reason, including prior transplant history
- Receiving transplant from either a 9/10 or 10/10 HLA-matched unrelated donor or cord blood
- Willing to attend an in-person 1-year long-term follow-up visit with oral medicine assessment at Fred Hutch
- Able to understand and sign informed consent (or have a legal representative do so)
You will not qualify if you...
- No natural teeth (edentulous state)
- Bone marrow as graft source
- Use of post-transplant cyclophosphamide (PTCy) or ruxolitinib for GVHD prevention
- Use of anti-thymocyte globulin (ATG) in conditioning
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fred Hutch/University of Washington Cancer Consortium
Seattle, Washington, United States, 98109
Actively Recruiting
Research Team
A
Armin Rashidi, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here