Actively Recruiting
Department of Defense PTSD Adaptive Platform Trial - Intervention A - Fluoxetine
Led by Global Coalition for Adaptive Research · Updated on 2025-09-08
200
Participants Needed
10
Research Sites
147 weeks
Total Duration
On this page
Sponsors
G
Global Coalition for Adaptive Research
Lead Sponsor
U
U.S. Army Medical Research and Development Command
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a Phase 2 randomized, double-blinded, placebo-controlled study that will evaluate multiple potential pharmacotherapeutic interventions for PTSD utilizing an adaptive platform trial design. Intervention A - Fluoxetine will assess the safety and efficacy of fluoxetine in participants with PTSD. Please see NCT05422612 for information on the S-21-02 Master Protocol.
CONDITIONS
Official Title
Department of Defense PTSD Adaptive Platform Trial - Intervention A - Fluoxetine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meet all inclusion criteria specified in the Master Protocol (NCT05422612)
You will not qualify if you...
- Recent history of treatment for PTSD with fluoxetine at doses of 20 mg daily for at least 4 weeks
- Remote history of fluoxetine treatment for non-PTSD symptoms will be reviewed case-by-case by the study medical monitor
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 10 locations
1
Phoenix VA Healthcare System
Phoenix, Arizona, United States, 85012-1839
Actively Recruiting
2
Homestead Associates in Research, Inc.
Miami, Florida, United States, 33032
Actively Recruiting
3
Advanced Discovery Research
Atlanta, Georgia, United States, 30318
Actively Recruiting
4
Tripler Army Medical Center (TAMC)
Tripler AMC, Hawaii, United States, 96859
Actively Recruiting
5
Cincinnati Veteran's Affairs Medical Center
Fort Thomas, Kentucky, United States, 41075
Actively Recruiting
6
Walter Reed National Military Medical Center (WRNMC)
Bethesda, Maryland, United States, 20889-5632
Actively Recruiting
7
Upstate Clinical Research Associates, LLC
Williamsville, New York, United States, 14221
Actively Recruiting
8
Wilford Hall Ambulatory Surgical Center (WHASC)
San Antonio, Texas, United States, 78236
Actively Recruiting
9
Alexander T. Augusta Military Medical Center (ATAMMC):
Fort Belvoir, Virginia, United States, 22060-5285
Actively Recruiting
10
Madigan Army Medical Center
Joint Base Lewis McChord, Washington, United States, 98433
Actively Recruiting
Research Team
P
Please visit the website:
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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