Actively Recruiting
Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)
Led by GlaxoSmithKline · Updated on 2026-04-09
960
Participants Needed
159
Research Sites
217 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Depemokimab is being developed as a treatment for individuals with moderate to severe COPD. The aim of this study is to assess the efficacy and safety of depemokimab compared as an add-on medicine in participants with uncontrolled moderate to severe COPD with type 2 inflammation.
CONDITIONS
Official Title
Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 40 to 80 years at the time of consent
- Elevated blood eosinophil count
- Clinically documented moderate to severe COPD for at least 1 year
- Post-bronchodilator FEV1/FVC ratio less than 0.70 and FEV1 between 30% and 80% of predicted normal
- History of at least 2 moderate or 1 severe COPD exacerbation in the past 12 months
- COPD assessment test (CAT) score of 10 or higher at first visit
- Current or former cigarette smokers with a smoking history of 10 or more pack-years
- On optimized inhaler therapy (ICS plus LAMA plus LABA) for at least 6 months before screening
- Body mass index of 16 kg/m2 or higher
- Male and eligible female participants
You will not qualify if you...
- Current or prior diagnosis of asthma
- Other significant lung diseases where COPD is not the primary diagnosis
- Pneumonia, COPD exacerbation, or lower respiratory infection within 4 weeks prior to screening
- History of or planned lung volume reduction surgery or endobronchial valve procedure
- Participation in acute phase of pulmonary rehabilitation within 4 weeks prior to screening
- Need for oxygen supplementation more than 12 hours per day
- Cor pulmonale causing right heart failure or severe pulmonary hypertension
- Chronic hypercapnia requiring non-invasive positive pressure ventilation (e.g., BiPAP or CPAP)
- Unstable heart disease or abnormal heart rhythms
- Known parasitic infection within 6 months prior to screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 159 locations
1
GSK Investigational Site
Sheffield, Alabama, United States, 35660
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2
GSK Investigational Site
Aurora, Colorado, United States, 80012
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3
GSK Investigational Site
Brooksville, Florida, United States, 346135
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4
GSK Investigational Site
Doral, Florida, United States, 33172
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5
GSK Investigational Site
Fort Lauderdale, Florida, United States, 33316
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6
GSK Investigational Site
Miami, Florida, United States, 33122
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7
GSK Investigational Site
Miami, Florida, United States, 33125
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8
GSK Investigational Site
Miami, Florida, United States, 33155
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9
GSK Investigational Site
Miami, Florida, United States, 33165
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10
GSK Investigational Site
Miami, Florida, United States, 33175
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11
GSK Investigational Site
Miami, Florida, United States, 33176
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12
GSK Investigational Site
Miami, Florida, United States, 33176
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13
GSK Investigational Site
Miami Lakes, Florida, United States, 33016
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14
GSK Investigational Site
Naples, Florida, United States, 34102
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15
GSK Investigational Site
New Port Richey, Florida, United States, 34653
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16
GSK Investigational Site
Ocala, Florida, United States, 34471
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17
GSK Investigational Site
Orlando, Florida, United States, 32825
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18
GSK Investigational Site
Ormond Beach, Florida, United States, 32174
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19
GSK Investigational Site
Palmetto Bay, Florida, United States, 33157
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20
GSK Investigational Site
St. Petersburg, Florida, United States, 33704
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21
GSK Investigational Site
Adairsville, Georgia, United States, 30103
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22
GSK Investigational Site
Cordele, Georgia, United States, 31015
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23
GSK Investigational Site
East Point, Georgia, United States, 30344
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24
GSK Investigational Site
Morrow, Georgia, United States, 30260
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25
GSK Investigational Site
Boise, Idaho, United States, 83702
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26
GSK Investigational Site
Chicago, Illinois, United States, 60608
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27
GSK Investigational Site
Baton Rouge, Louisiana, United States, 70816
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28
GSK Investigational Site
Lafayette, Louisiana, United States, 70506
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29
GSK Investigational Site
Shreveport, Louisiana, United States, 71105
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30
GSK Investigational Site
Bangor, Maine, United States, 04401
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31
GSK Investigational Site
Rockville, Maryland, United States, 20854
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32
GSK Investigational Site
Allen Park, Michigan, United States, 48101
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33
GSK Investigational Site
Detroit, Michigan, United States, 48202
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34
GSK Investigational Site
Garden City, Michigan, United States, 48135
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35
GSK Investigational Site
Troy, Michigan, United States, 48085
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36
GSK Investigational Site
Las Vegas, Nevada, United States, 89144
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37
GSK Investigational Site
Moorestown, New Jersey, United States, 08057
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38
GSK Investigational Site
Sewell, New Jersey, United States, 08080
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39
GSK Investigational Site
Mount Kisco, New York, United States, 10549
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40
GSK Investigational Site
New Windsor, New York, United States, 12553
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41
GSK Investigational Site
Shelby, North Carolina, United States, 28152
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42
GSK Investigational Site
DuBois, Pennsylvania, United States, 15801
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43
GSK Investigational Site
Philadelphia, Pennsylvania, United States, 19140
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44
GSK Investigational Site
Spartanburg, South Carolina, United States, 29303
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45
GSK Investigational Site
Union, South Carolina, United States, 29379
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46
GSK Investigational Site
Knoxville, Tennessee, United States, 37919
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47
GSK Investigational Site
Austin, Texas, United States, 78744
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48
GSK Investigational Site
Dallas, Texas, United States, 75254
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49
GSK Investigational Site
El Paso, Texas, United States, 79902-1123
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50
GSK Investigational Site
Houston, Texas, United States, 77094
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51
GSK Investigational Site
Lampasas, Texas, United States, 76550
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52
GSK Investigational Site
Richmond, Texas, United States, 77407
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53
GSK Investigational Site
San Antonio, Texas, United States, 78229
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54
GSK Investigational Site
Webster, Texas, United States, 77598
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55
GSK Investigational Site
Morgantown, West Virginia, United States, 26505-0423
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56
GSK Investigational Site
Buenos Aires, Argentina, C1425BAD
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57
GSK Investigational Site
Buenos Aires, Argentina, C1426ABP
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58
GSK Investigational Site
Córdoba, Argentina, X5800AEV
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59
GSK Investigational Site
Quilmes, Argentina, 1878
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60
GSK Investigational Site
Santa Fe, Argentina, S3000ASF
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61
GSK Investigational Site
Coffs Harbour, New South Wales, Australia, 2450
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62
GSK Investigational Site
Maroubra, New South Wales, Australia, 2035
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63
GSK Investigational Site
Westmead, New South Wales, Australia, 2145
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64
GSK Investigational Site
Midland, Western Australia, Australia, 6056
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65
GSK Investigational Site
Graz, Austria, 8036
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66
GSK Investigational Site
Innsbruck, Austria, 6020
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67
GSK Investigational Site
Klagenfurt, Austria, 9020
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68
GSK Investigational Site
Linz, Austria, 4020
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69
GSK Investigational Site
Linz, Austria, 4020
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70
GSK Investigational Site
Linz, Austria, 4021
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71
GSK Investigational Site
Vienna, Austria, A-1090
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72
GSK Investigational Site
Dupnitsa, Bulgaria, 2600
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73
GSK Investigational Site
Haskovo, Bulgaria, 6300
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74
GSK Investigational Site
Lovech, Bulgaria, 5500
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75
GSK Investigational Site
Montana, Bulgaria, 3400
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76
GSK Investigational Site
Montana, Bulgaria, 3400
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77
GSK Investigational Site
Pleven, Bulgaria, 5800
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78
GSK Investigational Site
Rousse, Bulgaria, 7002
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79
GSK Investigational Site
Rousse, Bulgaria, 7002
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80
GSK Investigational Site
Sofia, Bulgaria, 1510
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81
GSK Investigational Site
Sofia, Bulgaria, 1680
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82
GSK Investigational Site
Jindřichův Hradec, Czechia, 377 01
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83
GSK Investigational Site
Kralupy nad Vltavou, Czechia, 278 01
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84
GSK Investigational Site
Nymburk, Czechia, 288 02
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85
GSK Investigational Site
Prague, Czechia, 12000
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86
GSK Investigational Site
Varnsdorf, Czechia, 407 47
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87
GSK Investigational Site
Munich, Bavaria, Germany, 80335
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88
GSK Investigational Site
Offenbach, Hesse, Germany, 63065
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89
GSK Investigational Site
Rheine, North Rhine-Westphalia, Germany, 48431
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90
GSK Investigational Site
Bendorf, Germany, 56170
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91
GSK Investigational Site
Berlin, Germany, 10119
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92
GSK Investigational Site
Berlin, Germany, 10625
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93
GSK Investigational Site
Berlin, Germany, 10717
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94
GSK Investigational Site
Berlin, Germany, 10961
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95
GSK Investigational Site
Berlin, Germany, 12203
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96
GSK Investigational Site
Berlin, Germany, 12627
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97
GSK Investigational Site
Berlin, Germany, 13187
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98
GSK Investigational Site
Darmstadt, Germany, 64283
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99
GSK Investigational Site
Essen, Germany, 45127
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100
GSK Investigational Site
Fürstenwalde, Germany, 15517
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101
GSK Investigational Site
Geesthacht, Germany, 21502
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102
GSK Investigational Site
Giessen, Germany, 35392
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103
GSK Investigational Site
Halle, Germany, 6108
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104
GSK Investigational Site
Immenhausen, Germany, 34376
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105
GSK Investigational Site
Leipzig, Germany, 04207
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106
GSK Investigational Site
Leipzig, Germany, 04299
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107
GSK Investigational Site
Leipzig, Germany, 04347
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108
GSK Investigational Site
Lübeck, Germany, 23552
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109
GSK Investigational Site
Schleswig, Germany, 24837
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110
GSK Investigational Site
Exochi, Thessaloniki, Greece, 57010
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111
GSK Investigational Site
Alexandroupoli, Greece, 68100
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112
GSK Investigational Site
Athens, Greece, 115 21
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113
GSK Investigational Site
Ioannina, Greece, 45500
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114
GSK Investigational Site
Marousi, Greece, 151 25
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115
GSK Investigational Site
Ashkelon, Israel, 7830604
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116
GSK Investigational Site
Beer-Yaakov, Israel, 703000
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117
GSK Investigational Site
Beersheba, Israel, 84101
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118
GSK Investigational Site
Haifa, Israel, 30000
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119
GSK Investigational Site
Haifa, Israel, 3109601
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120
GSK Investigational Site
Haifa, Israel, 3436212
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121
GSK Investigational Site
Jerusalem, Israel, 90000
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122
GSK Investigational Site
Jerusalem, Israel, 91031
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123
GSK Investigational Site
Kfar Saba, Israel, 44281
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124
GSK Investigational Site
Petah Tikva, Israel, 49100
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125
GSK Investigational Site
Ramat Gan, Israel, 52621
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126
GSK Investigational Site
Catania, Italy, 95123
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127
GSK Investigational Site
Ferrara, Italy, 44124
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128
GSK Investigational Site
Foggia, Italy, 71122
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129
GSK Investigational Site
Genova, Italy, 16132
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130
GSK Investigational Site
Roma, Italy, 00128
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131
GSK Investigational Site
Roma, Italy, 00133
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132
GSK Investigational Site
Roma, Italy, 00161
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133
GSK Investigational Site
Telese Terme, Italy, 82037
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134
GSK Investigational Site
Daugavpils, Latvia, LV5410
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135
GSK Investigational Site
Riga, Latvia, LV 1079
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136
GSK Investigational Site
Riga, Latvia, LV-1002
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137
GSK Investigational Site
Takapuna, Auckland, New Zealand, 0622
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138
GSK Investigational Site
Auckland, New Zealand, 1051
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139
GSK Investigational Site
Auckland, New Zealand, 1051
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140
GSK Investigational Site
Christchurch, New Zealand, 8023
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141
GSK Investigational Site
Ebdentown, New Zealand, 5018
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142
GSK Investigational Site
Hamilton, New Zealand, 3240
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143
GSK Investigational Site
Rotorua, New Zealand, 3010
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144
GSK Investigational Site
Oradea, Bihor County, Romania, 410155
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145
GSK Investigational Site
Oradea, Bihor County, Romania, 410176
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146
GSK Investigational Site
Timișoara, Timiș County, Romania, 300310
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147
GSK Investigational Site
Bucharest, Romania, 061692
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148
GSK Investigational Site
Cluj-Napoca, Romania, 400275
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149
GSK Investigational Site
Cluj-Napoca, Romania, 400371
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150
GSK Investigational Site
Constanța, Romania, 900002
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151
GSK Investigational Site
Seoul, South Korea, 03181
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152
GSK Investigational Site
Seoul, South Korea, 5030
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153
GSK Investigational Site
Corby, United Kingdom, NN17 2UR
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154
GSK Investigational Site
Dagenham, United Kingdom, RM9 5NH
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155
GSK Investigational Site
Glasgow, United Kingdom, G20 7BE
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156
GSK Investigational Site
Glasgow, United Kingdom, G4 0SF
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157
GSK Investigational Site
London, United Kingdom, N8 0RA
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158
GSK Investigational Site
London, United Kingdom, NW10 2PB
Actively Recruiting
159
GSK Investigational Site
Uxbridge, United Kingdom, UB8 3NN
Actively Recruiting
Research Team
U
US GSK Clinical Trials Call Center
CONTACT
E
EU GSK Clinical Trials Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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