Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values.
R Rolke, R Baron, C Maier...
https://pubmed.ncbi.nlm.nih.gov/16697110Actively Recruiting
Age: 18Years - 65Years
All Genders
ID03037684
Selective Activation of Unmyelinated Skin Nerve Fibres Using Slow Depolarising Electrical Stimulation in Patients With Neuropathic Pain or Chronic Postoperative Pain
Led by Swiss Paraplegic Research, Nottwil · Updated on 2025-12-08
75
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying voltage gated sodium channel (NaV1.7) related pain in people with neuropathic pain and chronic postoperative pain. The goal is to better understand how these channels affect pain responses, especially in unmyelinated skin nerve fibers. This research focuses on characterizing pain in these conditions and how it relates to NaV1.7 channel activity. The study uses slow, sinus-like electrical skin stimulation to activate certain nerve fibers that may cause pain at low intensities in affected patients. Pain in chronic postoperative scars will also be examined using laser-evoked potentials (LEP) and a range of quantitative sensory tests (QST). Participants complete pain-related questionnaires to provide additional information about their pain experiences. Participants will undergo various assessments including pain intensity measurements during electrical stimulation, baseline sensory thresholds for heat, cold, and mechanical stimuli, and nerve response evaluations. Psychological aspects such as anxiety and depression are also measured. This observational study monitors changes over time without administering treatments. The total study period and participant involvement details are based on scheduled assessments and sensory testing.
CONDITIONS
Brief Title
Depolarising Electrical Skin Stimulation in Neuropathic and Postoperative Pain
Who Can Participate
Age: 18Years - 65Years
All Genders
Eligibility Criteria
You may qualify if you...
- Patients with neuropathic pain
- Patients with chronic postoperative pain
- Age between 18 and 65 years
- Both male and female participants
You will not qualify if you...
- Severe psychiatric disorder requiring hospitalization in the past
- Any neurological disease other than the pain diagnosis
- Outside the age range of 18 to 65 years
- Unable to participate in study procedures or assessments as required
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - 1 day
Participants undergo electrophysiologic measurements of peripheral nerves and quantitative sensory testing to characterize pain states and pain site features.
1 visit (in-person)
Long-term Monitoring
Duration - Duration of study participation
Participants complete pain-related questionnaires and assessments to monitor pain intensity and related health status over time.
Assessments at baseline and during electrical nerve stimulation as scheduled
Trial Site Locations
Total: 1 location
1
Centre for Pain Medicine
Nottwil, Switzerland, 6207
Actively Recruiting
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Research Team
G
Gunther Landmann, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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