Actively Recruiting

Age: 18Years +
All Genders
ID06193083

DEprescribing: Perceptions of Patients Living With Advanced Cancer A Multicentre, Prospective Mixed Observational Study

Led by Nantes University Hospital · Updated on 2026-02-11

325

Participants Needed

8

Research Sites

95 weeks

Total Duration

On this page

Sponsors

N

Nantes University Hospital

Lead Sponsor

F

Fondation de France

Collaborating Sponsor

AI-Summary

What this Trial Is About

This research aims to understand patients' views on deprescribing medications in palliative cancer care, focusing on the challenges of polymedication that can reduce quality of life and increase healthcare costs. The study also investigates factors influencing patients' beliefs about deprescribing and evaluates a questionnaire, the rPATD, to measure these perceptions in this specific population. The study consists of two main parts over three years. First, about 25 patients will participate in individual semi-structured interviews over eight months to gather detailed qualitative data. Then, a larger group of 300 patients will complete self-administered questionnaires, including the rPATD and the BMQ, over twelve months to quantify attitudes toward deprescribing. An additional questionnaire on health literacy will also be given during this second phase. Participants will be involved through interviews and questionnaires assessing their perceptions, beliefs, and literacy related to medication use and deprescribing. The researchers will analyze these responses to identify different patient profiles and factors affecting attitudes toward medication reduction. Outcomes focus on patients' perceptions at study entry, measured using validated tools, without treatment interventions. The study is observational and aims to improve deprescribing approaches in palliative oncology care.

CONDITIONS

Brief Title

DEprescribing: Perceptions of PAtients Living With Advanced Cancer

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient over 18 years of age
  • Diagnosed with locally advanced or metastatic solid cancer receiving palliative care
  • Life expectancy estimated by a physician to be less than 1 year
  • Currently hospitalized or attending consultations
  • Taking at least one potentially inappropriate medication identified by STOPPfrail 2
  • Has not refused to participate after receiving information from their physician
  • For qualitative study: signed consent for voice recording during interviews
Not Eligible

You will not qualify if you...

  • Under 18 years of age
  • Under guardianship or protected person
  • Unable to speak or write French
  • Has impaired judgment, cognitive, or sensory issues preventing informed consent or study participation
  • Has expressed opposition to participating in the study

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person or remote) to determine eligibility and obtain consent

Qualitative Study

Duration - Up to 8 months

Participants take part in semi-directed individual interviews to explore their perceptions of deprescribing in palliative cancer care.

1 to 2 interviews (in-person or remote) depending on participant availability

Quantitative Study

Duration - Up to 12 months

Participants complete self-administered questionnaires assessing their perceptions of treatments, beliefs about medicines, and health literacy.

1 visit to complete questionnaires (in-person or remote)

Trial Site Locations

Total: 8 locations

1

CHD Vendée

La Roche-sur-Yon, France, 85000

Not Yet Recruiting

2

Hospices Civils de Lyon

Lyon, France

Not Yet Recruiting

3

CHU de Nantes

Nantes, France, 44093

Actively Recruiting

4

USP - Maison de Nicodème

Nantes, France

Not Yet Recruiting

5

Hôpital Institut CURIE

Paris, France, 75005

Not Yet Recruiting

6

Institut de Cancérologie de l'Ouest

Saint-Herblain, France, 44800

Not Yet Recruiting

7

CH ST Nazaire

Saint-Nazaire, France, 44600

Not Yet Recruiting

8

CHRU Tours

Tours, France

Not Yet Recruiting

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Research Team

A

Adrien EVIN, MCU-PH

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Published Research Related To This Trial

DEprescribing: Perceptions of PAtients living with advanced cancer. A multicentre, prospective mixed observational study protocol.

Adrien Evin, Marianne Bourdon, Pierre Nizet...

https://pubmed.ncbi.nlm.nih.gov/39163415