Actively Recruiting
In-depth Analysis of the Immune Responses in the Upper Respiratory Tract in Older Adults Infected or Colonized With Streptococcus Pneumoniae (Spn)
Led by University Hospital, Geneva · Updated on 2025-05-31
280
Participants Needed
1
Research Sites
99 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The NoseSpn-Elderly study aims at characterizing the immune response in the upper respiratory tract in adults aged 60 and over diagnosed with a pneumonia due to a Streptococcus pneumoniae (Spn) infection. The immune response during the acute phase of the infection and after recovery will be compared to the immune response of asymptomatic Spn carriers as well as to the immune response of patients diagnosed with a viral respiratory infection (flu or respiratory syncytial virus (RSV)). The primary objective of this observational study is to quantify the inflammatory response in the nasal cavity and to correlate it with bacterial/viral load and with clinical parameters. The study also aims to compare the inflammatory response measured in the nose to that measured in the blood. Participants will have two study visits including a blood draw, several nasal samplings (nasal lining fluid and nasal cells) and a saliva sampling, one within 72 hours of their hospital admission and another one month later. Nasal lining fluid and saliva will be obtained every two or three days until discharge from the hospital or resolution of symptoms. During those visits, questions regarding symptoms will be asked.
CONDITIONS
Official Title
In-depth Analysis of the Immune Responses in the Upper Respiratory Tract in Older Adults Infected or Colonized With Streptococcus Pneumoniae (Spn)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 60 to 85 years
- Able to provide informed consent independently or with a legal representative
- For Spn pneumonia patients: clinical and/or radiological signs of pneumonia
- For Spn pneumonia patients: positive test for Spn by urinary antigen, blood culture, or sputum test
- For viral respiratory infection patients: clinical signs of respiratory infection
- For viral respiratory infection patients: positive test for influenza or RSV
- For asymptomatic Spn carriers: healthy without clinical infection signs and no lower respiratory symptoms in the past month
You will not qualify if you...
- Immunosuppression
- Use of inhalation and/or nasal steroids in the last month
- Intubation or invasive mechanical ventilation
- Long-term antibiotic treatment before disease onset
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Geneva University Hospitals
Geneva, Switzerland, 1205
Actively Recruiting
Research Team
J
Jennifer Villers, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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