Actively Recruiting
Descemet Endothelial Thickness Comparison Trial II
Led by Stanford University · Updated on 2026-05-08
60
Participants Needed
8
Research Sites
305 weeks
Total Duration
On this page
Sponsors
S
Stanford University
Lead Sponsor
O
Oregon Health and Science University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Descemet Endothelial Thickness Comparison Trial (DETECT) II is a multi-center, outcome assessor-masked, placebo-controlled clinical trial randomizing 60 patients with Fuchs endothelial dystrophy to DMEK versus Descemet Stripping Only (DSO) with adjunctive Ripasudil.
CONDITIONS
Official Title
Descemet Endothelial Thickness Comparison Trial II
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Dysfunctional endothelium from FECD with few guttata extending beyond 4.5 mm
- Peripheral endothelial cell count >1000 cells/mm2 in at least one quadrant
- Good surgical candidate for either procedure as determined by the surgeon
- Willingness to participate
- Age greater than 18 years
You will not qualify if you...
- Aphakia, anterior chamber IOL or scleral fixated IOL in study eye prior to or anticipated during EK
- Pre-operative central sub-epithelial or stromal scarring that may impact post-operative stromal clarity assessment
- Other primary endothelial dysfunction such as PPMD
- Visually significant optic nerve or macular pathology
- Hypotony (Intraocular pressure <10mmHg)
- Any prior intraocular surgery other than cataract surgery
- More than 3 clock hours of any anterior or posterior synechiae
- More than 1 quadrant of stromal corneal vascularization
- Inability to comply with post-operative instructions
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
Stanford University
Palo Alto, California, United States, 94303
Actively Recruiting
2
University of California Davis
Sacramento, California, United States, 95817
Actively Recruiting
3
University of Miami
Palm Beach Gardens, Florida, United States, 33418
Actively Recruiting
4
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03766
Actively Recruiting
5
Legacy Devers Eye Institute
Portland, Oregon, United States, 97210
Actively Recruiting
6
Oregon Health & Science University
Portland, Oregon, United States, 97239
Actively Recruiting
7
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
8
Wills Eye Hospital
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
Research Team
N
Nicole Varnado, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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