Actively Recruiting
Description of the Immune Response to Yellow Fever Vaccination
Led by Institut Pasteur · Updated on 2025-06-29
38
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are exploring a concept called innate immune memory, which may provide broad protection against infections beyond the specific disease targeted by a vaccine. This study focuses on the immune response triggered by a live attenuated vaccine for yellow fever and a subunit vaccine for typhoid, aiming to better understand how these vaccines might train the immune system in a non-specific way. The project is an exploratory clinical investigation conducted by Institut Pasteur. Participants in this study will receive primary immunization against yellow fever and typhoid through two vaccine appointments scheduled 7 days apart. Blood samples will be collected at multiple time points: at the start (day 0), week 1, week 5, month 3, and month 6 to observe changes in immune cells over time. The study will specifically analyze the immunological profile of peripheral blood mononuclear cells (PBMCs) before and after vaccination, as well as the response to the TyphimVi4 vaccine. Throughout the study, participants will undergo several blood draws to monitor immune responses across six months. Researchers will evaluate the immune system’s activity and memory after vaccination using these blood samples. The study includes adults aged 18 to 65 who require vaccination against yellow fever and typhoid. Safety and health status will be monitored, and participants must attend all scheduled visits, including one month after the typhoid vaccine injection, to complete the study assessments.
CONDITIONS
Brief Title
Description of the Immune Response to Yellow Fever Vaccination
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65 years
- Referred for immunisation against yellow fever and typhoid
- Have an indication for yellow fever and typhoid vaccinations
- Vaccination schedule includes two appointments 7 days apart
- Health status compatible with a single 51 ml blood sample collection
- Have consented to participate in the Ivory2 study
- Benefiting from a Social Security plan or equivalent
You will not qualify if you...
- Contraindication to yellow fever and/or typhoid vaccination
- Previously vaccinated against yellow fever and/or typhoid
- Lived in an endemic area for 1 year or more and/or history of typhoid
- Unable to attend the visit 1 month after the typhoid vaccine injection
- Pregnant or breastfeeding women
- Unable to give informed consent for participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
2 visits 7 days apart for vaccination appointments
Duration - 6 months
Participants have blood samples collected to observe the immune response after vaccination.
5 visits for blood sample collection at Day 0, Week 1, Week 5, Month 3, and Month 6
Trial Site Locations
Total: 1 location
1
Centre Médical de l'Institut Pasteur
Paris, France, 75015
Actively Recruiting
Research Team
J
Jessica Quintin, Dr
S
Sandrine Fernandes Pellerin
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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