Actively Recruiting
Description of the Immune Response to Yellow Fever Vaccination
Led by Institut Pasteur · Updated on 2025-06-29
38
Participants Needed
1
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Vaccine protection depends on a specific adaptive immune memory. However, a little-explored aspect of certain live vaccines may provide beneficial, non-specific protection against infections or pathogens other than the one from which the vaccine is derived. This is the concept of innate immune memory or " trained immunity", which differs from adaptive memory in its non-specificity. Innate immune memory is triggered by exposure to immunostimulants, and offers protection against unrelated pathogenic threats for several months or even years. The project aims to carry out an exploratory study to observe, in the context of current practice, the immune response obtained after a subunit and a live attenuated vaccine
CONDITIONS
Official Title
Description of the Immune Response to Yellow Fever Vaccination
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65
- Referred for immunisation against yellow fever and typhoid
- Any person with indication for the following vaccinations : Yellow fever, Typhoid
- Vaccination schedule includes two appointments 7 days apart
- Health condition allows for a single 51 ml blood sample collection
- Have consented to participate in the Ivory2 study
- Benefiting from a Social Security plan or equivalent
You will not qualify if you...
- Contraindication to yellow fever and/or typhoid vaccination
- Previously vaccinated against yellow fever and/or typhoid
- Lived in an endemic area for one year or more and/or history of typhoid
- Unable to attend the visit 1 month after the typhoid vaccine injection
- Pregnant or breastfeeding women
- Unable to give informed consent for participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centre Médical de l'Institut Pasteur
Paris, France, 75015
Actively Recruiting
Research Team
J
Jessica Quintin, Dr
CONTACT
S
Sandrine Fernandes Pellerin
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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