Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT05743738

Description of Septic Thrombophlebitis on Central Venous Catheter and Midline

Led by Centre Hospitalier le Mans · Updated on 2023-06-15

120

Participants Needed

2

Research Sites

160 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Central venous catheters improve the tolerability and feasibility of patient care in the hospital setting by allowing the administration of hyper-osmotic, vesicant and venotoxic fluids. Despite these advantages, the long-term presence of central venous catheters is associated with thrombotic and infectious risks , including catheter-related bacteremia, which can be complicated by septic thrombophlebitis and endocarditis that can lead to death. Septic thrombophlebitis is a complication of venous catheter infections, which increases the morbidity. It is defined by the presence of a thrombosis in the vein where the venous catheter is located, associated with a bacteremia. A distinction is made between superficial and deep thrombophlebitis. The frequency of septic thrombophlebitis of venous catheters is variable and poorly described in the literature. When the diagnosis of septic thrombophlebitis is made, it is recommended to extend the duration of antibiotic therapy, to remove the infected catheter and to prescribe anticoagulant treatment. However, there is no recommendation on the duration of anticoagulation for septic thrombophlebitis, whether it is deep or superficial. Investigator proposes a prospective and descriptive interventional study to describe the ultrasound evolution of thrombus in patients with septic thrombophlebitis on central venous catheter and midline.

CONDITIONS

Official Title

Description of Septic Thrombophlebitis on Central Venous Catheter and Midline

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adult patient hospitalized at the CHM or CHUA with a central venous device (implantable chamber, central venous jugular, femoral, subclavian, PICCline, dialysis catheter) or a midline catheter and catheter-related bacteremia
  • Catheter-related bacteremia defined by positive blood cultures within 48 hours of suspected catheter infection or removal, with differential time to positivity 2 hours before catheter removal, or positive catheter culture 2 103 CFU/ml with same organism after removal
  • Patient transportable for ultrasound or ultrasound can be performed at patient's bed
  • Patient capable of giving consent or consent given by trusted person if patient not capable
  • Written consent signed by participant and investigator
  • Person affiliated to social security
Not Eligible

You will not qualify if you...

  • Patient with life expectancy less than one month
  • Contraindication to anticoagulation
  • Patient already on curative anticoagulant therapy for any indication
  • Minor or adult patient under guardianship, protection, or deprived of liberty
  • Pregnant, nursing, or parturient woman

AI-Screening

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Trial Site Locations

Total: 2 locations

1

CHU Angers

Angers, France, 49000

Not Yet Recruiting

2

Centre Hospitalier Le Mans

Le Mans, France, 72 000

Actively Recruiting

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Research Team

C

Christelle JADEAU

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

DIAGNOSTIC

Number of Arms

2

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