Actively Recruiting
Description of Septic Thrombophlebitis on Central Venous Catheter and Midline
Led by Centre Hospitalier le Mans · Updated on 2023-06-15
120
Participants Needed
2
Research Sites
160 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Central venous catheters improve the tolerability and feasibility of patient care in the hospital setting by allowing the administration of hyper-osmotic, vesicant and venotoxic fluids. Despite these advantages, the long-term presence of central venous catheters is associated with thrombotic and infectious risks , including catheter-related bacteremia, which can be complicated by septic thrombophlebitis and endocarditis that can lead to death. Septic thrombophlebitis is a complication of venous catheter infections, which increases the morbidity. It is defined by the presence of a thrombosis in the vein where the venous catheter is located, associated with a bacteremia. A distinction is made between superficial and deep thrombophlebitis. The frequency of septic thrombophlebitis of venous catheters is variable and poorly described in the literature. When the diagnosis of septic thrombophlebitis is made, it is recommended to extend the duration of antibiotic therapy, to remove the infected catheter and to prescribe anticoagulant treatment. However, there is no recommendation on the duration of anticoagulation for septic thrombophlebitis, whether it is deep or superficial. Investigator proposes a prospective and descriptive interventional study to describe the ultrasound evolution of thrombus in patients with septic thrombophlebitis on central venous catheter and midline.
CONDITIONS
Official Title
Description of Septic Thrombophlebitis on Central Venous Catheter and Midline
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patient hospitalized at the CHM or CHUA with a central venous device (implantable chamber, central venous jugular, femoral, subclavian, PICCline, dialysis catheter) or a midline catheter and catheter-related bacteremia
- Catheter-related bacteremia defined by positive blood cultures within 48 hours of suspected catheter infection or removal, with differential time to positivity 2 hours before catheter removal, or positive catheter culture 2 103 CFU/ml with same organism after removal
- Patient transportable for ultrasound or ultrasound can be performed at patient's bed
- Patient capable of giving consent or consent given by trusted person if patient not capable
- Written consent signed by participant and investigator
- Person affiliated to social security
You will not qualify if you...
- Patient with life expectancy less than one month
- Contraindication to anticoagulation
- Patient already on curative anticoagulant therapy for any indication
- Minor or adult patient under guardianship, protection, or deprived of liberty
- Pregnant, nursing, or parturient woman
AI-Screening
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Trial Site Locations
Total: 2 locations
1
CHU Angers
Angers, France, 49000
Not Yet Recruiting
2
Centre Hospitalier Le Mans
Le Mans, France, 72 000
Actively Recruiting
Research Team
C
Christelle JADEAU
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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