Actively Recruiting
Desflurane vs. Propofol for Cardiac Anesthesia
Led by Xijing Hospital · Updated on 2025-11-25
3560
Participants Needed
14
Research Sites
219 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To investigate whether the inhaled anesthetic desflurane, compared with propofol, exerts cardioprotective effects and reduces the incidence of severe postoperative major cardiac events in patients undergoing coronary artery bypass graft (CABG) surgery.
CONDITIONS
Official Title
Desflurane vs. Propofol for Cardiac Anesthesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients scheduled for elective coronary artery bypass grafting (CABG)
- Age 18 years or older
- Signed informed consent form
You will not qualify if you...
- Emergency or urgent operation
- Concomitant valve or aortic surgery
- History of myocardial infarction in recent 30 days
- Current use of myocardial preconditioning-affecting medications such as sulfonylurea, allopurinol, theophylline, nicorandil (last dose < 8 hrs)
- Participation in other randomized controlled clinical trials in recent 3 months
- General anesthesia in recent 30 days
- History of kidney and liver transplantation or severe liver and kidney dysfunction (EGFR ≤ 20 ml/min/1.73 m², conventional dialysis or dialysis started; Child Pugh grade C/cirrhosis)
- History of open heart surgery
- Hemodynamic instability or severe heart failure (SBP <90 mmHg or need for high-dose vasoactive drugs, aortic balloon pump, ECMO, ventricular assist device, left ventricular ejection fraction <30%)
- Adverse drug reactions to trial medications
- History of malignant hyperthermia
- Pregnancy or lactation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 14 locations
1
Fuzhou University Affiliated Provincial Hospital
Fuzhou, Fujian, China
Not Yet Recruiting
2
Cangzhou People's Hospital
Cangzhou, Hebei, China
Not Yet Recruiting
3
Hebei General Hospital
Shijiazhuang, Hebei, China
Not Yet Recruiting
4
The First Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
Not Yet Recruiting
5
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Not Yet Recruiting
6
Wuhan Asia Heart Hospital
Wuhan, Hubei, China
Not Yet Recruiting
7
Jiangsu Province Hospital
Nanjin, Jiangsu, China
Not Yet Recruiting
8
Xijing Hospital
Xi'an, Shaanxi, China, 710032
Actively Recruiting
9
Sichuan Provincial People's Hospital
Chengdu, Sichuan, China
Not Yet Recruiting
10
Tianjin Chest Hospital
Tianjin, Tianjin Municipality, China
Actively Recruiting
11
Ningbo No.2 Hospital
Ningbo, Zhejiang, China
Not Yet Recruiting
12
Daping Hospital, Army Medical University
Chongqing, China
Not Yet Recruiting
13
Changhai Hospital
Shanghai, China
Actively Recruiting
14
Zhongshan Hospital, Fudan University
Shanghai, China
Not Yet Recruiting
Research Team
C
Chong Lei, M.D.& phd
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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