Actively Recruiting
DESIFOR-EXPAND (MHIF)
Led by Minneapolis Heart Institute Foundation · Updated on 2025-02-03
100
Participants Needed
1
Research Sites
99 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The DESIFOR pilot study was conducted to determine the feasibility of utilizing an n-of-1 trial to facilitate tolerance of unblinded rosuvastatin in patients with prior statin intolerance
CONDITIONS
Official Title
DESIFOR-EXPAND (MHIF)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (≥ 21 years old) with a prior history of statin intolerance. Statin intolerance is defined by discontinuation of at least 2 different statin medications due to possible side effects. Patients can participate in the trial while on other lipid-lowering agents, such as ezetimibe and PSCK9 inhibitors, as long as the patient has been on the other lipid lowering therapy and tolerating it well for at least 1 month. For individuals with established ASCVD or multiple ASCVD risk factors, initiation of other lipid lowering therapy prior to participation in DESIFOR is encouraged.
- 2. At least 30 days since discontinued use of a statin
You will not qualify if you...
- Women who are pregnant, nursing or attempting to become pregnant
- Individuals who experienced severe reactions in the past, including rhabdomyolysis, severe myositis, anaphylaxis
- Individuals who are not otherwise clinically indicated to take rosuvastatin 20 mg
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Minneapolis Heart Institute Foundation
Minneapolis, Minnesota, United States, 55407
Actively Recruiting
Research Team
G
Gretchen Program Director, RDN, CDCES
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
2
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