Actively Recruiting
DESTINY Breast Respond HER2-low Europe
Led by Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company · Updated on 2026-02-12
1155
Participants Needed
211
Research Sites
253 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Trastuzumab deruxtecan (T-DXd) as monotherapy is indicated for the treatment of adult patients with unresectable or metastatic HER2-low breast cancer who have received prior chemotherapy in the metastatic setting or developed disease recurrence during or within 6 months of completing adjuvant chemotherapy.
CONDITIONS
Official Title
DESTINY Breast Respond HER2-low Europe
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patient (age 2018 years or older) with histological or cytological confirmed diagnosis of unresectable and/or metastatic breast cancer
- Documented HER2-low status (IHC1+, IHC2+/ISH-)
- Patients who have received prior chemotherapy in the metastatic setting or developed disease recurrence during or within 6 months of completing adjuvant chemotherapy
- Decision to newly start treatment with Trastuzumab deruxtecan or conventional chemotherapy according to physician's choice per SmPC
- Written and signed informed consent to participate in the study
You will not qualify if you...
- Pregnancy or breastfeeding
- Patients currently participating or previously participated in a blinded interventional study at the time of data collection
- No other specific exclusion criteria as patients will be treated according to SmPC indication statements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 211 locations
1
Medizinische Universität Graz
Graz, Austria, 8036
Terminated
2
Medizinische Universität Graz
Graz, Austria, 8036
Active, Not Recruiting
3
Medizinische Universität Innsbruck
Innsbruck, Austria, 6020
Active, Not Recruiting
4
Klinikum Klagenfurt am Wörthersee
Klagenfurt, Austria, 9020
Active, Not Recruiting
5
LKH Hochsteiermark-Leoben
Leoben, Austria, 8700
Withdrawn
6
Ordensklinikum Linz GmbH Barmherzige Schwestern
Linz, Austria, 4010
Active, Not Recruiting
7
Interne II, LKH Feldkirch
Rankweil, Austria, 6830
Active, Not Recruiting
8
KH der Barmherzigen Brüder Salzburg
Salzburg, Austria, 5010
Active, Not Recruiting
9
Uniklinikum Salzburg
Salzburg, Austria, 5020
Active, Not Recruiting
10
Medical University of Vienna
Vienna, Austria, 1090
Active, Not Recruiting
11
Medizinische Universität Wien
Vienna, Austria, 1090
Terminated
12
Krankenhaus Hietzing
Vienna, Austria, 1130
Active, Not Recruiting
13
Salzkammergut Klinikum Vöcklabruck
Vöcklabruck, Austria, 4840
Active, Not Recruiting
14
Klinikum Wels-Grieskirchen GmbH
Wels, Austria, 4600
Active, Not Recruiting
15
Landesklinikum Wiener Neustadt
Wiener Neustadt, Austria, 2700
Active, Not Recruiting
16
ASZ Aalst
Aalst, Belgium, 9300
Active, Not Recruiting
17
Chirec Delta Hospital
Auderghem, Belgium, 1160
Active, Not Recruiting
18
Imeldaziekenhuis Bonheiden
Bonheiden, Belgium, 2820
Active, Not Recruiting
19
AZ Klina
Brasschaat, Belgium, 2930
Active, Not Recruiting
20
AZ Sint-Jan Brugge av
Bruges, Belgium, 8000
Active, Not Recruiting
21
CHU Brugmann
Brussels, Belgium, 1020
Active, Not Recruiting
22
Cliniques universitaires Saint-Luc
Brussels, Belgium, 1200
Active, Not Recruiting
23
Chu Helora- Hôpital de La Louvière- site Jolimont
Haine-Saint-Paul, Belgium, 7100
Active, Not Recruiting
24
Jessa Ziekenhuis
Hasselt, Belgium, 3500
Active, Not Recruiting
25
CHU Tivoli
La Louvière, Belgium, 7100
Active, Not Recruiting
26
CHC MontLegia
Liège, Belgium, 4000
Active, Not Recruiting
27
Hôpital de la Citadelle
Liège, Belgium, 4000
Active, Not Recruiting
28
CHU UCL Namur/Site Sainte Elisabeth
Namur, Belgium, B5000
Active, Not Recruiting
29
Clinique Saint Pierre Ottignies
Ottignies, Belgium, 1340
Active, Not Recruiting
30
VITAZ
Sint-Niklaas, Belgium, 9100
Active, Not Recruiting
31
CHR Verviers East Belgium
Verviers, Belgium, 4800
Active, Not Recruiting
32
Aalborg Universitetshospital, Syd
Aalborg, Denmark, 9000
Terminated
33
Aarhus University Hospital
Aarhus N, Denmark, 8200
Actively Recruiting
34
Herlev Hospital
Herlev, Denmark, 2730
Actively Recruiting
35
Onkologisk og Palliativ afdeling, Nordsjællands Hospital
Hillerød, Denmark, 3400
Actively Recruiting
36
Naestved Hospital
Næstved, Denmark, 4700
Actively Recruiting
37
Sygehus Sønderjylland, Sønderborg
Sønderborg, Denmark, 6400
Terminated
38
CHU Amiens Picardie
Amiens, France, 80000
Active, Not Recruiting
39
Clinique de l'Europe
Amiens, France, 80090
Actively Recruiting
40
Hôpital Privé d'Antony
Antony, France, 92160
Actively Recruiting
41
Hôpital Privé les Bonnettes
Arras, France, 62000
Actively Recruiting
42
Institut du Cancer Avignon Provence
Avignon, France, 84918
Actively Recruiting
43
CH Cote Basque
Bayonne, France, 64100
Actively Recruiting
44
Clinique Belharra
Bayonne, France, 64100
Withdrawn
45
Chu Jean Minjoz Besancon
Besançon, France, 25000
Active, Not Recruiting
46
Clinique Tivoli-Ducos
Bordeaux, France, 33000
Actively Recruiting
47
Centre hospitalier Fleyriat
Bourg-en-Bresse, France, 01012
Actively Recruiting
48
Centre Francois Baclesse
Caen, France, 14000
Actively Recruiting
49
Centre Hospitalier William Morey
Chalon-sur-Saône, France, 71321
Actively Recruiting
50
CH Metropole Savoie
Chambéry, France, 73000
Actively Recruiting
51
Pole Sante Leonard De Vinci
Chambray-lès-Tours, France, 37170
Actively Recruiting
52
CH Cholet
Cholet, France, 49300
Actively Recruiting
53
Centre Jean Perrin
Clermont-Ferrand, France, 63011
Actively Recruiting
54
Polyclinique St Côme
Compiègne, France, 60200
Actively Recruiting
55
Hôpital Henri Mondor
Créteil, France, 94000
Actively Recruiting
56
Centre Léonard de Vinci
Dechy, France, 59187
Actively Recruiting
57
Centre Georges Francois Leclerc
Dijon, France, 21000
Actively Recruiting
58
CHU Martinique
Fort de France Cedex, France, 97261
Actively Recruiting
59
CHI Frejus Saint Raphael
Fréjus, France, 83600
Actively Recruiting
60
Groupe Hospitalier Mutualiste (GHM) de Grenoble - Institut Daniel Hollard (IDH)
Grenoble, France, 38000
Actively Recruiting
61
Polyclinique De Blois
La Chaussée-Saint-Victor, France, 41260
Actively Recruiting
62
La Tronche - CHU Grenoble
La Tronche, France, 38700
Actively Recruiting
63
Centre de cancerologie de la Sarthe
Le Mans, France, 72100
Actively Recruiting
64
Centre Hospitalier Emile Roux
Le Puy-en-Velay, France, 43000
Actively Recruiting
65
Hôpital Franco-Britannique Cognac Jay
Levallois-Perret, France, 92300
Actively Recruiting
66
Centre Oscar Lambret
Lille, France, 59000
Actively Recruiting
67
CHU Lille
Lille, France, 59000
Actively Recruiting
68
Hôpital Prive Le Bois
Lille, France, 59000
Actively Recruiting
69
CHU de Limoges
Limoges, France, 87042
Actively Recruiting
70
Hospices Civils De Lyon
Lyon, France, 69002
Active, Not Recruiting
71
Hôpital Jean Mermoz
Lyon, France, 69008
Actively Recruiting
72
Hôpital-Clinique Claude Bernard
Metz, France, 57070
Withdrawn
73
GH Havre
Montivilliers, France, 76920
Actively Recruiting
74
Clinique Clementville
Montpellier, France, 34070
Actively Recruiting
75
Groupe Hospitalier privé Ambroise Pare Hartmann
Neuilly-sur-Seine, France, 92200
Actively Recruiting
76
Hopital Americain de Paris
Neuilly-sur-Seine, France, 92200
Actively Recruiting
77
Centre Antoine Lacassagne
Nice, France, 06100
Actively Recruiting
78
Centre Hospitalier de Niort
Niort, France, 79000
Actively Recruiting
79
Centre Médical ONCOGARD
Nîmes, France, 30029
Actively Recruiting
80
Institut Curie
Paris, France, 75005
Actively Recruiting
81
Groupement Hospitalier Diaconesses Croix Saint Simon
Paris, France, 75012
Actively Recruiting
82
Hopital Europeen Georges Pompidou
Paris, France, 75015
Actively Recruiting
83
Hôpital Saint Joseph
Paris, France, 75103
Actively Recruiting
84
Centre Hospitalier de Pau
Pau, France, 64000
Actively Recruiting
85
CHU Poitiers
Poitiers, France, 86000
Actively Recruiting
86
Institut Godinot
Reims, France, 51100
Actively Recruiting
87
Polyclinique Courlancy
Reims, France, 51100
Actively Recruiting
88
Centre Eugene Marquis
Rennes, France, 35042
Actively Recruiting
89
Clinique Saint Hilaire
Rouen, France, 76000
Withdrawn
90
Clinique Mathilde
Rouen, France, 76100
Actively Recruiting
91
Saint Cloud -Rene Huguenin Institut Curie
Saint-Cloud, France, 92210
Withdrawn
92
CHU Réunion Site Sud
Saint-Paul, France, 97460
Actively Recruiting
93
Institut De Cancerologie Paris Nord
Sarcelles, France, 95200
Actively Recruiting
94
Centre Hospitalier de Sens
Sens Cédex, France, 89108
Actively Recruiting
95
Hôpital Foch
Suresnes, France, 92150
Actively Recruiting
96
CHR Metz Thionville
Thionville, France, 57100
Actively Recruiting
97
HIA Sainte-Anne
Toulon, France, 83000
Actively Recruiting
98
Centre Hospitalier de Troyes
Troyes, France, 10000
Withdrawn
99
Hopital Prive Drome Ardeche
Valence, France, 26000
Actively Recruiting
100
Nouvelle Clinique Des Dentellières
Valenciennes, France, 59300
Actively Recruiting
101
Institut De Cancerologie De Lorraine
Vandœuvre-lès-Nancy, France, 54519
Withdrawn
102
Centre d'oncologie Saint-Yves
Vannes, France, 56000
Actively Recruiting
103
Médipôle Hôpital Mutualiste
Villeurbanne, France, 69100
Actively Recruiting
104
Azienda Ospedaliera di Alessandria
Alessandria, Italy, 15121
Actively Recruiting
105
Ospedale SS Annunziata
Chieti, Italy, 66100
Actively Recruiting
106
Ospedale Citta' di Castello USL Umbria 1
Città di Castello, Italy, 06012
Actively Recruiting
107
Ospedale San Giuseppe - Azienda USL Toscana Centro
Empoli, Italy, 50053
Actively Recruiting
108
ASL Lecce - Ospedale "Vito Fazzi"
Lecce, Italy, 42100
Withdrawn
109
ASST Lecco - PO "Alessandro Manzoni"
Lecco, Italy, 23900
Actively Recruiting
110
AULSS 9 Scaligera - Ospedale Mater Salutis
Legnago, Italy, 37045
Actively Recruiting
111
ASST Ovest Milanese - Ospedale di Legnano
Legnano, Italy, 90146
Actively Recruiting
112
Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST IRCCS
Meldola, Italy, 47014
Actively Recruiting
113
AOU di Modena
Modena, Italy, 73100
Actively Recruiting
114
Fondazione IRCCS San Gerardo dei Tintori
Monza, Italy, 20900
Actively Recruiting
115
AOU Federico II
Naples, Italy, 80131
Actively Recruiting
116
AOU Maggiore della Carità di Novara
Novara, Italy, 28100
Actively Recruiting
117
IOV - Istituto Oncologico Veneto - IRCCS
Padova, Italy, 35128
Actively Recruiting
118
La Maddalena S.p.A.
Palermo, Italy, 41124
Actively Recruiting
119
ARNAS Ospedale Civico e Benfratelli
Palermo, Italy, 90124
Actively Recruiting
120
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy, 27100
Actively Recruiting
121
AOU Pisana - Stabilimento Santa Chiara
Pisa, Italy, 89133
Actively Recruiting
122
AO Regionale San Carlo
Potenza, Italy, 85100
Actively Recruiting
123
Ospedale Generale Provinciale di Macerata
Province of Macerata, Italy, 62100
Actively Recruiting
124
GOM "BMM" - Presidio Ospedaliero Morelli
Reggio Calabria, Italy, 20025
Actively Recruiting
125
Azienda USL IRCCS di Reggio Emilia
Reggio Emilia, Italy, 31100
Actively Recruiting
126
ASL RM 2 Ospedale Pertini
Roma, Italy, 00157
Actively Recruiting
127
AO San Giovanni Addolorata
Roma, Italy, 00184
Actively Recruiting
128
AOU "San Giovanni di Dio e Ruggi d'Aragona"
Salerno, Italy, 84135
Actively Recruiting
129
IRCCS Ospedale Casa Sollievo della Sofferenza
San Giovanni Rotondo, Italy, 71013
Actively Recruiting
130
AOU Sassari - Ospedale Civile SS. Annunziata
Sassari, Italy, 56126
Actively Recruiting
131
Ospedale San Vincenzo
Taormina, Italy, 98039
Actively Recruiting
132
AOU Città della Salute e della Scienza di Torino - Ospedale Molinette
Torino, Italy, 10126
Actively Recruiting
133
AO Ordine Mauriziano
Torino, Italy, 10128
Actively Recruiting
134
AULSS n. 2 Marca trevigiana - Ospedale "Cà Foncello"
Treviso, Italy, 28100
Actively Recruiting
135
ASUFC Udine - Santa Maria della Misericordia
Udine, Italy, 33100
Actively Recruiting
136
ASST Sette Laghi "Ospedale di Circolo e Fondazione Macchi "
Varese, Italy, 22100
Actively Recruiting
137
Nordlandssjukhuset Bodø
Bodø, Norway, 8005
Actively Recruiting
138
Drammen Sykehus
Drammen, Norway, 3004
Actively Recruiting
139
Sørlandet sykehus / Kristiansand Hospital
Kristiansand, Norway, 4615
Actively Recruiting
140
Sykehuset Telemark
Skien, Norway, 3710
Actively Recruiting
141
Universitetssjukhuset Nord-Norge
Tromsø, Norway, 9019
Actively Recruiting
142
Hospital de Cascais
Alcabideche, Lisboa, Portugal, 2755-009
Not Yet Recruiting
143
ULS Amadora Sintra
Amadora, Lisboa, Portugal, 2720-276
Not Yet Recruiting
144
ULS Braga
Braga, Portugal, 4710-243
Not Yet Recruiting
145
IPO Lisboa
Lisbon, Portugal, 1023-099
Not Yet Recruiting
146
Dra. Berta Sousa
Lisbon, Portugal, 1400-038
Withdrawn
147
Hospital da Luz Lisboa
Lisbon, Portugal, 1500-650
Not Yet Recruiting
148
ULS Santa Maria
Lisbon, Portugal, 1649-035
Not Yet Recruiting
149
ULS Loures-Odivelas - Hospital Beatriz Ângelo
Loures, Portugal, 2674-514
Actively Recruiting
150
ULS Santo António
Porto, Portugal, 4099-001
Not Yet Recruiting
151
Instituto Português de Oncologia do Porto Francisco Gentil
Porto, Portugal, 4200-162
Not Yet Recruiting
152
ULS Matosinhos
Porto, Portugal, 4464-513
Not Yet Recruiting
153
ULS Trás-os-Montes e Alto Douro
Vila Real, Portugal, 5000-508
Not Yet Recruiting
154
Hospital Clinico Universitario de Albacete
Albacete, Spain, 02006
Actively Recruiting
155
Hospital Universitario de La Ribera
Alzira, Spain, 46600
Actively Recruiting
156
Hospital Universitario de Cruces
Barakaldo, Spain, 48903
Actively Recruiting
157
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain, 08026
Actively Recruiting
158
Hospital Universitario de Basurto
Bilbao, Spain, 48013
Actively Recruiting
159
Hospital Universitario de Puerto Real
Cadiz, Spain, 11510
Actively Recruiting
160
Hospital Universitario San Pedro de Alcántara
Cáceres, Spain, 10003
Actively Recruiting
161
Hospital Universitario Reina Sofia
Córdoba, Spain, 14004
Actively Recruiting
162
Hospital General Universitario de Elche
Elche, Spain, 03203
Actively Recruiting
163
Hospital de Galdakao
Galdakao, Spain, 48960
Actively Recruiting
164
Hospital Clinico Universitario de Granada (PTS)
Granada, Spain, 18016
Actively Recruiting
165
Hospital Universitario Médico-Quirúrgico de Jaén
Jaén, Spain, 23007
Actively Recruiting
166
Complejo Asistencial Universitario de León
León, Spain, 24008
Actively Recruiting
167
Hospital Universitario San Pedro de Logroño
Logroño, Spain, 26006
Withdrawn
168
Hospital Universitario Lucus Augusti
Lugo, Spain, 270003
Actively Recruiting
169
Hospital Universitario la Princesa
Madrid, Spain, 28006
Actively Recruiting
170
Hospital MD Anderson Cancer Center
Madrid, Spain, 28033
Actively Recruiting
171
Hospital Universitario Ramón y Cajal
Madrid, Spain, 28034
Actively Recruiting
172
Hospital Clínico Universitario San Carlos
Madrid, Spain, 28040
Actively Recruiting
173
Hospital Universitario 12 de Octubre
Madrid, Spain, 28041
Actively Recruiting
174
Hospital de Getafe
Madrid, Spain, 28905
Actively Recruiting
175
Hospital Virgen Arrixaca de Murcia
Murcia, Spain, 30120
Actively Recruiting
176
Hospital Universitario Central de Asturias
Oviedo, Spain, 330011
Actively Recruiting
177
Complejo Asistencial Universitario de Palencia
Palencia, Spain, 34005
Actively Recruiting
178
Hospital Son Llatzer
Palma, Spain, 07198
Actively Recruiting
179
Hospital Son Espases
Palma de Mallorca, Spain, 07210
Actively Recruiting
180
Hospital de Pontevedra
Pontevedra, Spain, 36001
Actively Recruiting
181
Hospital San Joan de Reus
Reus, Spain, 43204
Actively Recruiting
182
Hospital Universitari Parc Taulí
Sabadell, Spain, 08208
Actively Recruiting
183
Complejo Asistencial Universitario de Salamanca
Salamanca, Spain, 37007
Actively Recruiting
184
Hospital Universitario de Canarias
San Cristóbal de La Laguna, Spain, 38320
Actively Recruiting
185
Hospital General de Catalunya
Sant Cugat del Vallès, Spain, 08195
Actively Recruiting
186
Hospital Universitario Marqués de Valdecilla
Santander, Spain, 39008
Actively Recruiting
187
Hospital Universitario General de Valencia
Valencia, Spain, 46014
Actively Recruiting
188
Hospital Clínico de Valladolid
Valladolid, Spain, 47003
Actively Recruiting
189
Hospital Universitario Rio Hortega
Valladolid, Spain, 47012
Actively Recruiting
190
Complejo Hospitalario Universitario De Vigo
Vigo Pontevedra, Spain, 36312
Actively Recruiting
191
Onkologikliniken Mälarsjukhuset
Eskilstuna, Sweden, 63188
Actively Recruiting
192
Gävle Hospital
Gävle, Sweden, 80324
Actively Recruiting
193
Ryhov County Hospital
Jönköping, Sweden, 55185
Actively Recruiting
194
Department of Oncology, Örebro University Hospital
Örebro, Sweden, 70185
Actively Recruiting
195
Capio St Görans sjukhus
Stockholm, Sweden, 11912
Actively Recruiting
196
Bröstcentrum, Karolinska Universitetssjukhuset Solna
Stockholm, Sweden, 17176
Actively Recruiting
197
Onkologkliniken Sundsvalls Sjukhus
Sundsvall, Sweden, 85643
Withdrawn
198
Cancercentrum, Norrlands Universitetssjukhus
Umeå, Sweden, 901 85
Actively Recruiting
199
Department of Oncology, Västerås
Västerås, Sweden, 72335
Actively Recruiting
200
Kantonsspital Baden
Baden, Switzerland, 5404
Active, Not Recruiting
201
Spital Thurgau AG - Kantonsspital Frauenfeld
Frauenfeld, Switzerland, 8500
Terminated
202
Centre du sein Fribourg
Fribourg, Switzerland, 1701
Active, Not Recruiting
203
Clinique Generale-Beaulieu / Clinique de Genolier
Geneva, Switzerland, 1206
Active, Not Recruiting
204
Réseau Hospitalier Neuchâtelois (RHNe)
La Chaux-de-Fonds, Switzerland, 2300
Active, Not Recruiting
205
Réseau du Sein Lausanne
Lausanne, Switzerland, 1003
Active, Not Recruiting
206
CHUV
Lausanne, Switzerland, 1011
Active, Not Recruiting
207
Kantonsspital Baselland
Liestal, Switzerland, 4410
Active, Not Recruiting
208
Kantonsspital St.Gallen
Sankt Gallen, Switzerland, 9007
Not Yet Recruiting
209
Hôpital du Valais Sion
Sion, Switzerland, 1951
Active, Not Recruiting
210
ZIO AG
Zurich, Switzerland, 8005
Active, Not Recruiting
211
Universitätsspital Zürich
Zurich, Switzerland, 8091
Active, Not Recruiting
Research Team
C
Contact for Clinical Trial Information
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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