Actively Recruiting
DESTINY-PANTUMOUR04
Led by AstraZeneca · Updated on 2026-05-01
100
Participants Needed
17
Research Sites
132 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will evaluate the effectiveness of T-DXd in patients with HER2-positive (IHC 3+) locally advanced, unresectable, or metastatic solid tumors who have received prior systemic treatment for metastatic or advanced disease and have no satisfactory alternative treatment options in a real-world setting in the US
CONDITIONS
Official Title
DESTINY-PANTUMOUR04
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 618 years
- Patients with locally advanced, unresectable, or metastatic HER2-positive (IHC 3+) solid tumors who have received prior systemic treatment for metastatic or advanced disease and have no satisfactory alternative treatment options
- A clinician decision has been made for treatment with T-DXd according to the FDA label
- HER2-positive (IHC 3+) status confirmed by local testing before enrollment
- Patients willing and able to provide signed and dated informed consent
You will not qualify if you...
- Diagnosis of adenocarcinoma of the breast, adenocarcinoma of the colon or rectum, NSCLC, adenocarcinoma of the gastric body or gastroesophageal junction, or hematological malignancies
- Prior treatment with trastuzumab deruxtecan (T-DXd)
- No baseline tumor burden assessment before starting T-DXd
- Participation in another clinical trial at the time of enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 17 locations
1
Research Site
Birmingham, Alabama, United States, 35243
Actively Recruiting
2
Research Site
Bullhead City, Arizona, United States, 86442
Actively Recruiting
3
Research Site
Casa Grande, Arizona, United States, 85122
Actively Recruiting
4
Research Site
San Diego, California, United States, 92123
Actively Recruiting
5
Research Site
Boulder, Colorado, United States, 80309
Actively Recruiting
6
Research Site
Coral Springs, Florida, United States, 33065
Actively Recruiting
7
Research Site
St. Petersburg, Florida, United States, 33714
Actively Recruiting
8
Research Site
West Palm Beach, Florida, United States, 33401
Actively Recruiting
9
Research Site
Decatur, Illinois, United States, 62526
Actively Recruiting
10
Research Site
Topeka, Kansas, United States, 66604
Actively Recruiting
11
Research Site
Durham, North Carolina, United States, 27708
Actively Recruiting
12
Research Site
Wilson, North Carolina, United States, 27893
Actively Recruiting
13
Research Site
Canton, Ohio, United States, 44718
Actively Recruiting
14
Research Site
Maumee, Ohio, United States, 43537
Actively Recruiting
15
Research Site
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
16
Research Site
Nashville, Tennessee, United States, 37203
Actively Recruiting
17
Research Site
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
A
AstraZeneca Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here