Actively Recruiting
Detecting Mild Autonomous Cortisol Secretion in Patients With Adrenal Incidentaloma
Led by The Cleveland Clinic · Updated on 2026-01-08
20
Participants Needed
1
Research Sites
318 weeks
Total Duration
On this page
Sponsors
T
The Cleveland Clinic
Lead Sponsor
R
RECORDATI GROUP
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of the proposed study is to estimate the incidence of Mild Autonomous Cortisol Secretion (MACS) in patients with Adrenal Incidentaloma (AI) and evaluate the available diagnostic tests to determine the most sensitive and specific combination of tests for assessing MACS from adrenal adenoma for prediction of the phenotype associated with cortisol excess. As well as following the patients for 4 years and see if anything changes.
CONDITIONS
Official Title
Detecting Mild Autonomous Cortisol Secretion in Patients With Adrenal Incidentaloma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients ages 18 years and older
- Presence of adrenal incidentaloma confirmed by CT or MRI scan
- 1-mg Dexamethasone suppression test cortisol level less than or equal to 5 µg/dL with adequate dexamethasone level
You will not qualify if you...
- 1-mg Dexamethasone suppression test cortisol level greater than 5 µg/dL with adequate dexamethasone level (indicating possible Cushing's syndrome)
- Current or recent (within 3 months) use of glucocorticoid medications including steroid joint injections
- History of uncontrolled hypertension or hypertension requiring more than 2 medications
- History of uncontrolled type 2 diabetes mellitus or diabetes with A1c greater than 7.5
- Known history of osteoporosis
- Documented clinical Cushing's disease
- Clinical suspicion of adrenal carcinoma
- History of alcohol abuse or dependence
- History of liver cirrhosis
- History of hepatitis B or C infection
- History of type 1 diabetes
- History of hemochromatosis
- History of autoimmune hepatitis
- History of Wilson's disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
K
Kimberly Jenkins
CONTACT
A
Andrea Parianos
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here