Actively Recruiting
Detection of Alzheimer's Disease (AD)-Related Seeds for AD Diagnosis
Led by Capital Medical University · Updated on 2026-03-23
1500
Participants Needed
1
Research Sites
331 weeks
Total Duration
On this page
Sponsors
C
Capital Medical University
Lead Sponsor
S
Shandong Provincial Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study will investigate the biomarkers of Aβ and Tau seeds in plasma detected by Alzheimer's disease (AD) related seeds quantitative detector (AD-seeds-detector), and their sensitivity and specificity in diagnosing AD, compared with those from age-matched cognitively normal controls, and those with other types of dementia. To perform a high throughput analysis of the amount of Aβ and Tau seeds, the investigators have developed an AD-seeds-detector, in which a fluorescence microplate reader was combined with an oscillating mixer or water-bath-type ultrasonicator.
CONDITIONS
Official Title
Detection of Alzheimer's Disease (AD)-Related Seeds for AD Diagnosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 55 to 75 years
- Written informed consent obtained from participant or legal guardian before any study procedures
- Diagnosis of Alzheimer's Disease made using National Institute on Aging and Alzheimer's Association criteria
- Diagnosis of non-Alzheimer's dementia made using appropriate criteria for each type (e.g., DLB, bvFTD, semantic variant FTD, PDD, VaD, CBD, CJD)
- Normal cognition confirmed by MMSE, CDR, or other cognitive function tests
You will not qualify if you...
- Presence of other medical or psychiatric illnesses
- Lack of an informant to provide information
- Refusal to complete cognitive testing or provide biospecimens
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Xuanwu Hospital of Capital Medical University
Beijing, Beijing Municipality, China, 100053
Actively Recruiting
Research Team
J
Jianping Jia, Doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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