Actively Recruiting
Detection of Azole Resistance Inducing Mutations on DNA Extracted Directly From Serum or Plasma of Immunocompromised Patients With an Invasive Aspergillus Infection Azole Resistance PCR Optimalization-study
Led by Bart Rijnders · Updated on 2024-05-07
300
Participants Needed
1
Research Sites
704 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Invasive aspergillosis (IA) is the most common mould infection in immunocompromised patients with haematological disease. Voriconazole, a triazole, improves overall survival of patients with an IA and is the mainstay of therapy. Resistance of A. Fumigatus emerged as an important clinical problem and infections with azole resistant Aspergillus have a high mortality. Nowhere in the world, azole resistance is more prevalent than in the Netherlands. Rapid detection of resistance is key to improve the patient's outcome but fungal cultures take time and are often negative. The investigators aim to detect azole resistance associated mutations in fungal DNA extracted directly from serum or plasma to accelerate diagnosis and improve outcome of patients infected with azole resistant A. fumigatus.
CONDITIONS
Official Title
Detection of Azole Resistance Inducing Mutations on DNA Extracted Directly From Serum or Plasma of Immunocompromised Patients With an Invasive Aspergillus Infection Azole Resistance PCR Optimalization-study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years or older
- Lung CT shows lesions that meet radiological criteria for possible invasive fungal infection
- Bronchoalveolar lavage planned or performed within the previous 48 hours
You will not qualify if you...
- Unable or unwilling to provide consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Erasmus Medical Center (EMC)
Rotterdam, South Holland, Netherlands, 3000 CA
Actively Recruiting
Research Team
B
Bart Rijnders, MD, PhD
CONTACT
H
Hanne Lamberink, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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