Actively Recruiting
Detection and Characterization of Infections and Infection Susceptibility
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-05-07
2000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This screening study will examine the causes of immune disorders affecting white blood cells, which defend against infections and will try to develop better means of diagnosis and treatment of these immune disorders. This is a 2 visit screening study and patients determined to be of interest for additional study or treatment will be asked to provide consent for enrollment into an appropriate NIH follow up study. This study does not cover the cost of the first visit to NIH for travel or lodgings but does cover the subsequent visit if there is one. A financial assessment may determine if the patient is eligible for financial assistance. This study does not enroll children under the age of 2. Patients known to have or suspected of having increased susceptibility to infections and their blood relatives may be eligible for this study, at the discretion of the principal investigator. Patients and family members may undergo the following procedures: * Personal and family medical history. * Physical examination and blood and urine tests. * Studies of breathing function (pulmonary function testing) * Dental examination. * Eye examination. * Genetic Testing * Stored specimens for future analysis * Microscopic examination of saliva, wound drainage or tissues removed for medical reasons for cell, hormone or DNA studies. In addition, patients will be asked to obtain permission for investigators to obtain their medical records, previous test results, or radiographic studies prior to the first visit. Patients will be asked to undergo imaging studies, such as a chest X-ray, CT scan or MRI scan.
CONDITIONS
Official Title
Detection and Characterization of Infections and Infection Susceptibility
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients known or suspected to have infection susceptibility and their healthy blood relatives are eligible.
- Participants must be older than 1 month of age.
- Enrollment includes all sexes, races, and disabilities.
- Patients must have a primary physician outside NIH and may need to submit a health history letter.
- Participants or their guardians must be willing and able to provide informed consent.
- Agreement to have blood and tissue stored for future immune system or medical studies is required.
- Concurrent enrollment in other protocols is allowed if the Principal Investigator is informed.
- Relatives may enroll only if the patient is enrolled.
- Children are included; those not meeting Clinical Center criteria may have sample collection only.
- Decisionally impaired adults can participate with consent from legally authorized representatives.
- Patients losing consent capacity during the study may continue participation under protections.
You will not qualify if you...
- Patients with well-known acquired conditions causing infection susceptibility like HIV, chemotherapy, or active cancer may be excluded if these interfere with evaluation.
- Severe or uncommon infections requiring specialized care not available at NIH may be grounds for exclusion as determined by the Principal Investigator.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
C
Carla D Williams, R.N.
CONTACT
S
Steven M Holland, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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