Actively Recruiting
Detection and Characterization of Neurologic Manifestations of Inborn and Acquired Errors of Immunity
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2025-09-25
350
Participants Needed
1
Research Sites
1028 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Immune system and nervous system have significant interaction so that People with immunity diseases can have complications that affect the nervous system and people with some neurological disease may have defects in their immune system.These complications can affect many body functions, including how they move, walk, think, and feel. Researchers do not fully understand how immune diseases affect the nervous system. By learning more, they hope to create more effective treatments. Objective: To learn more about the interaction between immune and nervous system and how immunity disease affect the nervous system. Eligibility: People aged 2 years and older with an immunity disease. Their healthy biological relatives and other healthy volunteers are also needed. Design: Participants will be screened. Blood will be drawn for research. They may have imaging scans. Adults may undergo lumbar puncture: A needle will be inserted into their back to collect fluid from the space around the spinal cord. The imaging scans and lumbar puncture will be optional for healthy relatives and volunteers. All participants will have 1 study visit per year for 5 years. They will be asked to donate samples of body fluids at each visit. Blood samples are required for the study. All other donations are optional. These may include saliva, urine, breast milk, stool, vaginal secretions, and wound drainage. Affected participants may be asked for a skin biopsy: A small sample of skin will be removed. They may also be photographed or videotaped to record the symptoms of their disease. Tests for each study visit may be spread over several days, if needed. Visits may be at the clinic. Participants may also collect their own samples at home and send them to the researchers....
CONDITIONS
Official Title
Detection and Characterization of Neurologic Manifestations of Inborn and Acquired Errors of Immunity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 2 years or older (participants seen at NIH Clinical Center must be 3 years or older)
- Willing to allow storage of specimens and data for future research
- Willing to allow genetic testing on biospecimens
- Able to provide informed consent or have parent/guardian consent if under 18
- Decisionally impaired adults may have a legally authorized representative provide consent
- For affected participants: Have a primary or acquired immunodeficiency with known or suspected nervous system infection, inflammation, or post-infection complications
- Affected participants must have a primary health care provider outside NIH
- For biological relatives and healthy volunteers: Be a biological relative or unrelated
- Biological relatives and volunteers must not have known neuroinfectious disease or neuroinflammation
You will not qualify if you...
- Pregnant (applies to biological relatives and healthy volunteers)
- Any condition judged by investigator to pose undue risk or make participation unsuitable
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
K
Kelsey L Yoo, P.A.-C
CONTACT
F
Farinaz Safavi, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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