Actively Recruiting
Detection of Endometrial Cancer Through Risk Modelling
Led by University of British Columbia · Updated on 2026-04-16
1000
Participants Needed
1
Research Sites
116 weeks
Total Duration
On this page
Sponsors
U
University of British Columbia
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study goal is to investigate a non-invasive approach to predict endometrial cancer (EC) risk, better understand disease progression and identify opportunities for intervention. This two-part case-cohort prospective study will recruit patients whose abnormal uterine bleeding is being evaluated via endometrial biopsy. Participants will complete an online health questionnaire, and a subset will be invited to self-collect vaginal samples for sequencing. Selected sequenced participants will be invited for longitudinal monitoring (questionnaires, wearable fitness tracker) and an additional vaginal self-collection to identify persistent genetic mutations or microbiome alterations 6-8 months later.
CONDITIONS
Official Title
Detection of Endometrial Cancer Through Risk Modelling
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 40 years and older
- Experiencing unexplained abnormal uterine bleeding (not caused by IUD or similar)
- Have an intact uterus
- Referred for an endometrial biopsy
- For longitudinal monitoring: selected for sequencing and retained their uterus
You will not qualify if you...
- Endometrial sampling, pelvic radiation, or vaginal infection in the past 3 months
- Started hormone therapy (HRT, birth control, IUD) in the past year except tamoxifen
- Had intercourse, used vaginal products, or douched within the past 48 hours
- For longitudinal monitoring: diagnosed with endometrial cancer or EIN, or recommended for hysterectomy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
VGH Research Pavilion
Vancouver, British Columbia, Canada, V5Z 1M9
Actively Recruiting
Research Team
A
Aline Talhouk, PhD
CONTACT
J
Jennifer Ellis-White
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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