Actively Recruiting
Prospective Study on Detection and Prediction of Clinically Significant Pneumothorax After Image-guided Transthoracic Lung Biopsy
Led by Chinese University of Hong Kong · Updated on 2025-03-11
330
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate how well a chest X-ray (CXR) taken 4 hours after an image-guided transthoracic lung biopsy (TTLB) can detect clinically significant pneumothorax, a common complication where air leaks into the space around the lungs. The study focuses on whether the absence of pneumothorax on this 4-hour CXR can predict the absence of significant pneumothorax at 16 to 20 hours after the biopsy. This is a prospective observational study conducted at a tertiary referral center in Hong Kong to improve safety and patient management after TTLB. Patients undergoing image-guided TTLB, either by CT or ultrasound guidance, will have CXRs performed at three time points: within 1 hour after the biopsy, around 4 hours post-biopsy, and again at about 18 hours. The presence and size of pneumothorax will be recorded using several measurement methods. This schedule aims to identify delayed pneumothorax early and help decide if patients can be safely discharged the same day. Participants will be monitored through these scheduled CXRs, and data will be collected about pneumothorax occurrence and clinical outcomes. The study will measure the accuracy of the 4-hour CXR in predicting later pneumothorax and evaluate risk factors and treatment outcomes. The information gathered intends to support safer discharge planning and reduce hospital stays for patients undergoing lung biopsy.
CONDITIONS
Brief Title
Detection and Prediction of Clinically Significant Pneumothorax After Image-guided Transthoracic Lung Biopsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients scheduled for image-guided transthoracic lung biopsy (TTLB) including ultrasound or CT guidance for diagnosis
- Patients able to provide written informed consent to participate in the study
You will not qualify if you...
- Patients whose lung lesion has resolved before the scheduled TTLB
- Patients with active worsening respiratory conditions such as COPD flare-ups or pneumonia
- Patients with psychiatric disease or cognitive impairment limiting consent ability
- Patients who decline to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo image-guided transthoracic lung biopsy followed by chest X-rays (CXRs) to detect pneumothorax at specific time points.
3 visits (in-person) within 18 hours after biopsy
Duration - Up to 18 months
Participants are monitored for clinical outcomes and the occurrence of pneumothorax after the initial diagnostic period.
Follow-up visits as scheduled during the study period
Trial Site Locations
Total: 1 location
1
Chinese University of Hong Kong
Hong Kong, Hong Kong
Actively Recruiting
Research Team
K
Ka Pang Chan, MBChB
K
Ka Pang Chan, MBChB
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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