Detection of Sepsis Occurrence Using Blood Fluorescence A Study to Explore a Sensitive, Reagent-Free Blood Test for Early Sepsis Detection

What this Trial Is About

Researchers are investigating a new blood fluorescence metabolite analyzer to improve early detection of sepsis. Sepsis is hard to diagnose early because current methods like qSOFA and SOFA scores often confirm the disease only after organ damage has occurred, increasing the risk of death. This study aims to develop a reagent-free, highly sensitive tool that can screen frequently for inflammatory free radicals in the blood, which appear early in sepsis before organ damage. The study collects blood samples from admitted and discharged patients, including healthy controls and those with varying severities of infection. A 10 cc fasting blood sample is drawn, processed by centrifugation, and then analyzed using a specialized blood fluorometer to measure fluorescence intensity changes linked to sepsis. This diagnostic test does not interfere with clinical diagnosis or treatment and is performed under strict quality control to ensure accurate and reliable results. Participants include healthy individuals with no recent hospitalizations and patients with confirmed or suspected infections categorized by qSOFA and SOFA scores. The study assesses the specificity and sensitivity of blood fluorescence intensity for diagnosing sepsis over one year. Researchers collect clinical data, perform blood fluorescence measurements, and monitor participants to evaluate the test's ability to detect sepsis early, aiming to reduce diagnosis time and improve patient outcomes.

Detection of Sepsis Occurrence by Using Blood Fluorescence