Using Indocyanine Green and Near-Infrared Fluorescence Imaging to Identify Tumor Edges and Depth in Superficial Esophageal and Gastric Cancers During Endoscopic Submucosal Dissection

What this Trial Is About

Researchers are evaluating the use of indocyanine green ICG-enhanced near-infrared quantified fluorescence molecular endoscopy qFME during endoscopic submucosal dissection ESD to better determine the depth and margin of superficial esophageal and gastric adenocarcinomas T1. These cancers affect the upper gastrointestinal tract, and current techniques may not always fully remove tumors, leading to recurrence risks. This study aims to assess whether ICG-enhanced qFME can improve tumor visualization during ESD. Participants will receive a systemic injection of indocyanine green approximately 30 minutes before undergoing ESD. Near-infrared qFME imaging will then be performed during the endoscopic procedure to help detect tumor boundaries and depth. This method is being studied as a tool to potentially enhance tumor demarcation in the upper gastrointestinal tract. During the study, researchers will evaluate the feasibility of using ICG-enhanced qFME to identify tumor depth and margins one week after the procedure and after study completion within about eight months. They will also assess how well this imaging technique can visualize other nearby structures such as the papilla of Vater and biliary anatomy. Participants will be closely monitored with imaging and assessments related to the endoscopic procedure and fluorescence imaging.

Detection of Upper Gastrointestinal Tumour Depth and Demarcation Using Systemic Administration of Indocyanine Green During Endoscopic Submucosal Dissection