Actively Recruiting

Phase Not Applicable
Age: 21Years +
All Genders
NCT06308094

320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation.

Led by Johns Hopkins University · Updated on 2026-04-13

100

Participants Needed

1

Research Sites

85 weeks

Total Duration

On this page

Sponsors

J

Johns Hopkins University

Lead Sponsor

C

Canon Medical Systems, USA

Collaborating Sponsor

AI-Summary

What this Trial Is About

This study explores the relationship between myocardial fibrosis and patient outcomes in Atrial Fibrillation (AF), specifically after catheter ablation. It aims to use Cardiac CT, an accessible tool, to measure left ventricular extracellular volume (ECV) as an indicator of fibrosis. The study will assess if higher ECV levels correlate with increased risks of AF recurrence, hospitalization, and poor cardiac function recovery. Positive findings could make ECV a key factor in deciding AF treatment strategies.

CONDITIONS

Official Title

320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation.

Who Can Participate

Age: 21Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients must be at least 21 years old at the time of enrollment.
  • Patients must be able to give informed consent.
  • Patients with symptomatic paroxysmal or persistent atrial fibrillation (AF).
  • Patients must be deemed suitable candidates for AF ablation by their cardiologist or electrophysiologist.
  • Patients scheduled to have a pre-procedure cardiac CT scan as decided by their electrophysiologist.
Not Eligible

You will not qualify if you...

  • Known allergy to iodinated contrast media.
  • Elevated serum creatinine greater than 1.5 mg/dl or creatinine clearance less than 60 ml/min.
  • Positive urine or serum pregnancy test.
  • History of heart transplantation.
  • Presence of polymorphic ventricular tachycardia or electrical storm.
  • Any condition that investigator considers problematic.
  • Iodinated contrast given for other reasons within 24 hours before the investigational CT.
  • Presence of heart pacemaker, metallic foreign body in the eye, aneurysm clip in the brain, mechanical heart valves, or metal-containing prosthetics.
  • Severe claustrophobia.

AI-Screening

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Trial Site Locations

Total: 1 location

1

Johns Hopkins Hospital

Baltimore, Maryland, United States, 21287

Actively Recruiting

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Research Team

K

Konstantinos Aronis, MD PHD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

DIAGNOSTIC

Number of Arms

1

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