Actively Recruiting
320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation
Led by Johns Hopkins University · Updated on 2026-04-13
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
C
Canon Medical Systems, USA
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are exploring the link between myocardial fibrosis and outcomes in patients with Atrial Fibrillation (AF) after catheter ablation. The study focuses on using Cardiac CT to measure left ventricular extracellular volume (ECV) as a sign of fibrosis. It aims to see if higher ECV levels are connected to greater risks of AF returning, hospitalizations, and poor heart function recovery. This could help guide AF treatment decisions. Participants who are referred for catheter ablation will undergo an extra CT scan to measure ECV before the procedure. This is done during the standard pre-ablation cardiac CT that maps heart anatomy. The study uses a 320-detector CT to quantify ECV, a widely available and high-resolution method compared to MRI. The research assesses if ECV expansion relates to AF burden. During the study, outcomes such as AF recurrence and cardiovascular-related emergency visits or hospitalizations will be tracked for up to 90 days after the procedure. Heart function changes will be measured by ejection fraction, and quality of life will be assessed using the Atrial Fibrillation Effect on Quality-of-Life questionnaire. Participants will be monitored carefully during this period to evaluate these clinical outcomes.
CONDITIONS
Brief Title
320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must be at least 21 years old at the time of enrollment.
- Patients must be able to give informed consent.
- Patients with symptomatic paroxysmal or persistent atrial fibrillation.
- Patients must be suitable candidates for ablation to treat atrial fibrillation as determined by their cardiologist or electrophysiologist.
- Patients are scheduled to have a pre-procedure cardiac CT as decided by their electrophysiologist.
You will not qualify if you...
- Known allergy to iodinated contrast media.
- Elevated serum creatinine above 1.5 mg/dl or creatinine clearance below 60 ml/min.
- Positive urine or serum pregnancy test.
- History of heart transplantation.
- Presence of polymorphic ventricular tachycardia or electrical storm.
- Any other condition the investigator considers problematic.
- Iodinated contrast administration within 24 hours prior to the investigational CT.
- Presence of heart pacemaker, metallic foreign bodies in the eye, brain aneurysm clips, mechanical heart valves, or metal-containing prosthetics.
- Severe claustrophobia.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single day
Participants undergo a pre-ablation cardiac CT scan with additional imaging to measure myocardial extracellular volume (ECV) to assess myocardial fibrosis before atrial fibrillation ablation.
1 visit (in-person)
Duration - Up to 90 days
Participants are monitored for up to 90 days after the ablation procedure to assess recurrence of atrial fibrillation, cardiovascular events, changes in heart function, and quality of life.
Follow-up visits during 90-day post-procedure period
Trial Site Locations
Total: 1 location
1
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287
Actively Recruiting
Research Team
K
Konstantinos Aronis, MD PHD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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