The effect of exercise training on biventricular myocardial strain in heart failure with preserved ejection fraction.
Siddhartha S Angadi, Catherine L Jarrett, Moustafa Sherif...
https://pubmed.ncbi.nlm.nih.gov/28772048Actively Recruiting
Phase Not Applicable
Age: 18Years - 85Years
All Genders
ID07182955
Determinants of Cardiorespiratory Fitness and Effects of High Intensity Interval Training (HIIT) in Patients With Angina and No Obstructive Coronary Artery Disease (ANOCA)
Led by University of Virginia · Updated on 2025-09-19
25
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the causes of reduced fitness in patients with Angina and No Obstructive Coronary Artery Disease (ANOCA) and whether a targeted high-intensity interval training (HIIT) exercise program can improve their heart function, fitness, and quality of life. The study aims to better understand the link between poor cardiorespiratory fitness and quality of life in these patients by using cardiopulmonary exercise testing (CPET) to identify exercise limitations and phenotypes. Participants will undergo a 4-week remote HIIT exercise program involving three non-consecutive days per week. The program begins with one supervised treadmill session, followed by remote sessions monitored with Polar heart rate devices and an app. Exercise sessions progressively increase from one-minute intervals to four 4-minute sessions. Participants will wear a wrist-based Polar device daily and a chest strap during exercise to monitor heart rate and adherence. During the study, participants will have baseline and post-exercise CPET assessments to measure peak oxygen consumption and exercise fitness. Questionnaires will assess angina symptoms, cardiac anxiety, functional status, and quality of life. Researchers will track adherence to exercise and evaluate changes in fitness and quality of life after the HIIT program. The study duration for each participant is 4 weeks of intervention with assessments before and after training.
CONDITIONS
Brief Title
Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)
Who Can Participate
Age: 18Years - 85Years
All Genders
Eligibility Criteria
You may qualify if you...
- Age 18 to 85 years
- Anginal symptoms of chest pain or exertional breathlessness suspected due to myocardial ischemia with no obstructive coronary artery disease confirmed by invasive or CT coronary angiogram
- Able to use a wearable device and participate in a remote exercise program
- Able to perform intermittent high-intensity training
- Able to complete cardiopulmonary exercise testing (CPET)
- Able to provide health-related quality of life questionnaire responses
- Able to understand and provide informed consent in English and complete study questionnaires in English
You will not qualify if you...
- Systolic heart failure with left ventricular ejection fraction less than 50% or NYHA class III symptoms
- Prior myocardial infarction or coronary revascularization
- Unable to safely undergo cardiopulmonary exercise testing
- Pregnancy
- Unable to provide informed consent
- Life expectancy less than 1 year
- Prisoner status
- Cognitive impairment
- Non-English speaking
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Run-in Period
Duration - Up to 1 week
Participants undergo baseline cardiopulmonary exercise testing (CPET) and complete health-related quality of life questionnaires before starting the exercise program.
1 baseline visit (in-person)
Treatment
Duration - 4 weeks
Participants engage in a remote 4-week high-intensity interval exercise training program on three non-consecutive days per week, starting with one supervised treadmill session and followed by remote sessions using a Polar heart rate monitor.
1 supervised exercise session and remote exercise sessions three days per week
Follow-up
Duration - Within 1 week after treatment
Participants undergo repeat cardiopulmonary exercise testing and complete health-related quality of life questionnaires to assess changes after the exercise program.
1 follow-up visit (in-person)
Trial Site Locations
Total: 1 location
1
University of Virginia Health System
Charlottesville, Virginia, United States, 22908
Actively Recruiting
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Research Team
R
Rahel Askari
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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Published Research Related To This Trial
Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial.
Rainer Hambrecht, Claudia Walther, Sven Möbius-Winkler...
https://pubmed.ncbi.nlm.nih.gov/15007010