Actively Recruiting
Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)
Led by University of Virginia · Updated on 2025-09-19
25
Participants Needed
1
Research Sites
35 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main goal is to understand what causes reduced fitness in ANOCA and whether targeted exercise can help improve it. This study aims to better understand why patients with Angina and No Obstructive Coronary Artery Disease (ANOCA) have poor cardiorespiratory fitness and its effect on quality of life. Investigators also want to see if a structured high-intensity exercise program (HIIT), done with remote monitoring, can safely improve heart function, fitness, and quality of life in these patients. The Investigators will use a special exercise test called cardiopulmonary exercise testing to look for patterns that can help explain exercise limitations and quality of life in ANOCA before and after a remote high-intensity exercise program.
CONDITIONS
Official Title
Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 85 years
- Anginal symptoms of chest pain or exertional dyspnea suspected to be from myocardial ischemia
- No obstructive epicardial coronary artery disease confirmed by invasive or CT coronary angiography
- Able to use a wearable device and participate in a remote exercise program
- Able to participate in intermittent high-intensity training
- Able to perform cardiopulmonary exercise testing (CPET)
- Able to provide health-related quality of life questionnaire (HRQOL) data
- Able to understand and provide informed consent in English and complete study questionnaires in English
You will not qualify if you...
- Systolic heart failure with left ventricular ejection fraction less than 50% or NYHA class III symptoms
- Prior myocardial infarction or coronary revascularization
- Unable to safely undergo cardiopulmonary exercise testing based on investigator judgment
- Pregnancy
- Unable to provide informed consent
- Life expectancy less than 1 year
- Prisoners
- Cognitive impairment
- Non-English speaking
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Virginia Health System
Charlottesville, Virginia, United States, 22908
Actively Recruiting
Research Team
R
Rahel Askari
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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