Actively Recruiting
Determinants of Repeated Spontaneous Miscarriages and Unexplained Fetal Deaths
Led by University Hospital, Brest · Updated on 2026-03-20
200
Participants Needed
1
Research Sites
1930 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The DEFI-1 study recruited 625 women witnesses and 299 of their spouses. With regard to case couples, 271 cases were recruited from the spontaneous repeated miscarriages (SRM) subgroup (≥3 spontaneous miscarriage (SM) from trimester 1 of pregnancy) and 93 from the unexplained fetal death in utero (FDIU) subgroup from trimesters 2 and 3 of pregnancy. The main objective of the DEFI 2 study is to increase the number of case-pairs in these 2 particular subgroups to replicate the results of the genetic determinants highlighted from cases and controls with extreme phenotypes and obtain a sufficient number of women with FDIUs to identify specific determinants.
CONDITIONS
Official Title
Determinants of Repeated Spontaneous Miscarriages and Unexplained Fetal Deaths
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Couples where the woman is between 18 and 40 years old inclusive
- Couples with at least 3 unexplained spontaneous miscarriages in the first trimester or fetal death in utero during the second or third trimester (excluding funicular, fetal causes, and preeclampsia)
- Male partner must be 18 years old or older
- Both members of the couple must consent to participate
- Participants must have social security coverage
You will not qualify if you...
- Woman under 18 or over 40 years old
- Male partner under 18 years old
- Identified cause of spontaneous repeated miscarriage or fetal death in utero
- Inability of either member to consent
- Refusal to participate by either member of the couple
- Women currently treated with anticoagulants or anti-platelet medications
- Persons under legal protection
- Participants without social security coverage
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
BREST
Brest, France, 29200
Actively Recruiting
Research Team
E
Elisabeth Pasquier, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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