Study of Blood Protein Levels Linked to Blood Vessel Leakage in Patients with Systemic Inflammatory Response Syndrome

What this Trial Is About

Researchers are investigating the role of specific proteins in vascular leakage, which is linked to higher risk of death during conditions like Sepsis and systemic inflammatory response syndrome SIRS. This observational study aims to understand how certain proteins, identified from earlier research, relate to blood vessel leakage and its impact on patient outcomes during SIRS. The study focuses on patients admitted to intensive care units who develop SIRS. Participants will have blood samples taken on the day SIRS begins Day 0 and then on Days 1, 3, and 7 to measure protein levels using a lab technique called ELISA. If clinically necessary, fluid samples from the lungs will also be collected and analyzed. The study will examine the relationship between protein levels and clinical measures like fluid balance, lung water content, organ failure scores, and severity of respiratory distress. During the study, patients will be closely monitored with regular blood tests and clinical assessments at specified timepoints. Researchers will record fluid balance, lung function, organ failure, and survival status up to 30 days. The study plans to include 180 patients over five years to identify proteins linked to vascular leakage and outcomes. This information may help find new markers for disease severity and potential treatment targets.

Determinants of Vascular Leakage During Systemic Inflammatory Response Syndrome