Actively Recruiting
Determination of Biomarkers of the Effectiveness of Deep Brain Stimulation by Direct Electrophysiological Recordings of Brain Activity in a Cognitive Context - LFP-DBS 2024
Led by Centre Hospitalier St Anne · Updated on 2025-02-06
250
Participants Needed
2
Research Sites
605 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Deep brain stimulation (DBS) is a therapeutic approach aimed at applying high-frequency, low-intensity electrical stimulation using electrodes implanted in subcortical structures and connected subcutaneously to a stimulator implanted in the abdomen. In recent years, new indications have been studied for severe and drug-resistant forms of several neurological and neuropsychiatric pathologies. Its non-lesional, reversible and customizable nature make it a therapy of choice. However, several factors are currently slowing down the evolution and optimization of SCP. The identification of objective, quantifiable and predictive criteria for the therapeutic effects of stimulation would allow an acceleration of the individualized identification of the therapeutic parameters of SCP. The surgical procedure for implanting the stimulation equipment is carried out in several stages, which offer unique opportunities to acquire individual imaging or electrophysiology data that are potentially predictive of the therapeutic effect of DBS. In order to continue the optimization of DBS procedures, and therefore to maximize its therapeutic effects, it seems crucial to us to take advantage of all the neurophysiological data likely to be collected during this procedure. Furthermore, given the multiplication of indications for SCP, it seems necessary to highlight specific markers. Thus, the use of neurocognitive and/or motor tests specific to each pathology and coupled with electrophysiological recordings and anatomical and functional examinations would make it possible to highlight specific functional biomarkers predictive of therapeutic effects.
CONDITIONS
Official Title
Determination of Biomarkers of the Effectiveness of Deep Brain Stimulation by Direct Electrophysiological Recordings of Brain Activity in a Cognitive Context - LFP-DBS 2024
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patient
- Patient suffering from a pathology requiring treatment with deep brain stimulation: neurological disease (e.g.: Parkinson Disease, Essential Tremors, dystonia, epilepsy, etc.) or psychiatric disease (e.g.: Obsessive Compulsive Disorder, depression, eating disorders, etc.)
- Patient capable of understanding the study procedures and completing the self-questionnaires in French
- Patient informed and having signed the informed consent form
You will not qualify if you...
- Contraindications to DBS, neurosurgery or anesthesia
- Patients with significant hemorrhagic or infectious risks
- Patient unable to perform the neurocognitive or sensorimotor tests
- Patient who is not a beneficiary of a social security system
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Grenoble-Alpes Hospital Center
Grenoble, France, 38043
Not Yet Recruiting
2
Groupe Hospitalo-Universitaire Paris Psychiatrie et Neurosciences, Paris
Paris, France, 75014
Actively Recruiting
Research Team
P
Philippe Domenech, Professor, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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